Do personality characteristics predict future alcohol problems after considering current demography, substance use, and alcohol response?

Author:

Schuckit Marc A.1ORCID,Smith Tom L.2,Danko George1,Bucholz Kathleen K.3ORCID,Hesselbrock Victor4ORCID,Hesselbrock Michie4,Kuperman Samuel5,Kramer John6ORCID,Nurnberger John I.7,Lai Dongbing8ORCID,Chan Grace9ORCID,Kamarajan Chella10ORCID,Kuo Sally11,Dick Danielle M.12ORCID,Tear Jake13,Mendoza Lee Anne1,Edenberg Howard J.14ORCID,Porjesz Bernice15

Affiliation:

1. Department of Psychiatry University of California, San Diego La Jolla California USA

2. University of California, San Diego La Jolla California USA

3. Washington University School of Medicine, Psychiatry Saint Louis Missouri USA

4. Department of Psychiatry University of Connecticut Farmington Connecticut USA

5. Child Psychiatry Clinic, UIHC Department of Psychiatry The University of Iowa Iowa City Iowa USA

6. Psychiatry University of Iowa Iowa City Iowa USA

7. Department of Psychiatry Indiana University School of Medicine Indianapolis Indiana USA

8. Indiana University School of Medicine Indianapolis Indiana USA

9. Department of Psychiatry University of Connecticut Health Center Farmington Connecticut USA

10. Henri Begleiter Neurodynamics Lab SUNY Downstate Medical Center Brooklyn New York USA

11. VCU Psychology Virginia Commonwealth University Richmond Virginia USA

12. Psychiatry Rutgers Robert Wood Johnson Medical School Piscataway New Jersey USA

13. Department of Psychiatry University of California La Jolla California USA

14. Department of Biochemistry and Molecular Biology Indiana University School of Medicine Indianapolis Indiana USA

15. Psychiatry and Behavioral Sciences State University of New York, Downstate Brooklyn New York USA

Abstract

AbstractBackgroundSeveral personality traits predict future alcohol problems but also relate to demographic and substance‐related variables that themselves correlate with later adverse alcohol outcomes. Few prospective studies have evaluated whether personality measures predict alcohol problems after considering current demographic and substance‐related variables.MethodsData from 414 drinkers without alcohol use disorder (AUD) from the Collaborative Study on the Genetics of Alcoholism (average age 20, 44% male) were followed over an average of 9 years. Time 1 (baseline) demography, AUD family history (FH), substance use and problems, and psychiatric histories were gathered using a standardized interview; the Level of Response (LR) to alcohol was measured by the Self‐Report of the Effects of alcohol (SRE) questionnaire; and seven personality dimensions were extracted from the NEO Five‐Factor Personality, Barratt, and Zuckerman scales. Analyses involved product–moment correlations of each baseline measure with the highest number of DSM‐IV AUD criteria endorsed in any follow‐up period, and hierarchical regression analyses evaluated whether the personality domains added significantly to the prediction of the outcome after adjusting for other baseline variables.ResultsSignificant correlations with the outcome were observed for baseline age, sex, length of follow‐up, AUD family history, past cannabis use, and all alcohol‐related baseline variables, including SRE‐based LR, but not prior mood or anxiety disorders. All personality characteristics except extraversion also correlated with outcomes. A hierarchical regression analysis that included all relevant personality scores together demonstrated significant contributions to the prediction of future alcohol problems for demographics in Step 1; demographics and most baseline alcohol items, including response level, in Step 2; and cannabis use in Step 3; after which demographics, LR, baseline alcohol problems, cannabis use, and higher sensation seeking added significantly in Step 4. Regression for each personality domain separately revealed significant contributions to Step 4 for all personality domains except openness. Lower levels of response to alcohol added significantly to all regression analyses.ConclusionsMost tested personality scores and lower levels of response to alcohol contributed to predictions of later alcohol problems even after considering baseline demographic and substance use measures.

Funder

National Institute on Alcohol Abuse and Alcoholism

National Institute on Drug Abuse

Publisher

Wiley

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