Randomised trial of acid inhibition by vonoprazan 10/20 mg once daily vs rabeprazole 10/20 mg twice daily in healthy Japanese volunteers (SAMURAI pH study)

Author:

Takeuchi Toshihisa1ORCID,Furuta Takahisa2ORCID,Fujiwara Yasuhiro3ORCID,Sugimoto Mitsushige4ORCID,Kasugai Kunio5,Kusano Motoyasu6,Okada Hiroyuki7,Suzuki Takahiro8,Higuchi Tomohiro8,Kagami Takuma8,Uotani Takahiro8,Yamade Mihoko8,Sawada Akinari3ORCID,Tanaka Fumio3ORCID,Harada Satoshi9,Ota Kazuhiro9,Kojima Yuichi1,Murata Masaki4,Tamura Yasuhiro5,Funaki Yasushi5,Kawamura Osamu6,Okamoto Yuki7,Fujimoto Kazuma10,Higuchi Kazuhide9

Affiliation:

1. Endoscopic Center; Osaka Medical College Hospital; Takatsuki Japan

2. Center for Clinical Research; Hamamatsu University School of Medicine; Hamamatsu Japan

3. Department of Gastroenterology; Osaka City University Graduate School of Medicine School of Medicine; Osaka Japan

4. Division of Digestive Endoscopy; Shiga University of Medical Science Hospital; Otsu Japan

5. Department of Gastroenterology; Aichi Medical University; Aichi Japan

6. Department of Endoscopy and Endoscopic Surgery; Gunma University Hospital; Meabashi Japan

7. Department of Gastroenterology and Hepatology; Dentistry and Pharmaceutical Sciences; Okayama University Graduate School of Medicine; Okayama Japan

8. First Department of Medicine; Hamamatsu University School of Medicine; Hamamatsu Japan

9. Second Department of Internal Medicine; Osaka Medical College; Takatsuki Japan

10. Department of Internal Medicine; Saga Medical School; Saga Japan

Funder

EA Pharma Co., Ltd.,

Publisher

Wiley

Subject

Pharmacology (medical),Gastroenterology,Hepatology

Reference48 articles.

1. Update on the epidemiology of gastro-ooesophageal reflux disease: a systematic review;El-Serag;Gut,2014

2. Gastro-oesophageal reflux disease: the recent trend in Japan;Miwa;Clin J Gastroenterol,2008

3. Swedish Council on Health Technology Assessment (SBU) Dyspepsia and gastro-ooesophageal reflux: a systematic review

4. Relationship between intragastric acid control and healing status in the treatment of moderate to severe erosive oesophagitis;Katz;Aliment Pharmacol Ther,2007

5. Nexium® (esomeprazole) US Prescribing Information 2018 https://dailymed.nlm.nih.gov/dailymed/

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