Inhibition of hyaluronan synthesis attenuates pulmonary hypertension associated with lung fibrosis

Author:

Collum Scott D1,Chen Ning-Yuan1,Hernandez Adriana M1,Hanmandlu Ankit1,Sweeney Heather1,Mertens Tinne C J1,Weng Tingting1,Luo Fayong1,Molina Jose G1,Davies Jonathan2,Horan Ian P3,Morrell Nick W3,Amione-Guerra Javier4,Al-Jabbari Odeaa4,Youker Keith4,Sun Wenchao5,Rajadas Jayakumar5,Bollyky Paul L6,Akkanti Bindu H7,Jyothula Soma7,Sinha Neeraj4,Guha Ashrith4,Karmouty-Quintana Harry1ORCID

Affiliation:

1. Department of Biochemistry and Molecular Biology; McGovern Medical School, UTHealth; Houston TX USA

2. Department of Paediatrics; Baylor College of Medicine; Houston TX USA

3. Cambridge BHF Centre for Cardiovascular Research Excellence; University of Cambridge School of Clinical Medicine; Cambridge UK

4. Debakey Heart & Vascular Center; Houston Methodist Hospital; Houston TX USA

5. Biomaterials and Advanced Drug Delivery Lab; Stanford University School of Medicine; Stanford CA USA

6. Division of Infectious Diseases, Department of Medicine; Stanford University School of Medicine; Stanford CA USA

7. Internal Medicine UTHealth; Houston TX USA

Funder

American Heart Association

Entelligence Young Investigators Award

2013 Entelligence MD Actelion Award

Publisher

Wiley

Subject

Pharmacology

Reference56 articles.

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2. The Concise Guide to PHARMACOLOGY 2015/16: Enzymes;Alexander;Br J Pharmacol,2015a

3. The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors;Alexander;Br J Pharmacol,2015b

4. Targeting RhoA/ROCK pathway in pulmonary arterial hypertension;Antoniu;Expert Opin Ther Targets,2012

5. Inhibition of hyaluronan retention by 4-methylumbelliferone suppresses osteosarcoma cells in vitro and lung metastasis in vivo;Arai;Br J Cancer,2011

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