Causal relationship between worry, tension, insomnia, sensitivity to environmental stress and adversity, and erectile dysfunction: a study using Mendelian randomization

Author:

Zhang Hao1ORCID,Wang Shiqi2,Ma Sicheng3,Zhang Chenming4ORCID,Wang Zulong2,Yan Peiyu15

Affiliation:

1. Faculty of Chinese Medicine Macau University of Science and Technology, Macao Taipa Macao SAR China

2. The First Affiliated Hospital, Henan University of Chinese Medicine Zhengzhou China

3. Zhongjing Academy, Henan University of Traditional Chinese Medicine Zhengzhou China

4. The Second Clinical Medical College, Henan University of Chinese Medicine Zhengzhou China

5. State Key Laboratory of Quality Research in Chinese Medicines Macau University of Science and Technology Zhuhai MUST Science and Technology Research Institute Macau University of Science and Technology, Macao Taipa Macao SAR China

Abstract

AbstractBackgroundThis study aims to investigate the causal relationship between erectile dysfunction (ED) and psychological states including worry, tension, insomnia, sensitivity to environmental stress and adversity (SESA).MethodThis study the used two‐sample bi‐directional Mendelian randomization (MR) method. The study data was obtained from a pooled dataset of genome‐wide association studies (GWAS). The bi‐directional MR analysis was performed using inverse variance weighting, weighted median method, and MR‐Egger regression analysis to assess the causality between ED and psychological states including worry, tension, insomnia, SESA in terms of odd ratios (OR). The study tested for heterogeneity using the Cochran Q method and for multiple validity using the MR‐Egger and MR‐PRESSO methods.ResultsIn forward MR analysis correlating worry, tension, insomnia, and SESA as exposures, no causal relationship was found between worry or tension and ED (p < 0.05). However, insomnia (p = 0.001, OR = 3.441, 95%CI = 1.593–7.435) and SESA (p = 0.004, OR = 1.804, 95%CI = 1.203–2.701) were found to have a significant causal effect on ED risk. The reverse MR analysis with ED as the exposure did not show any significant correlation (all p > 0.05).ConclusionIndividuals with insomnia and SESA are at higher risk for developing ED. Clinical evaluation should be more thorough for these individuals. Insomnia can be treated simultaneously with psychological counseling to reduce the risk of ED. In addition, there is no evidence to suggest that worry and tension increase the risk of ED.

Funder

Fundo para o Desenvolvimento das Ciências e da Tecnologia

National Natural Science Foundation of China

Publisher

Wiley

Subject

Urology,Endocrinology,Reproductive Medicine,Endocrinology, Diabetes and Metabolism

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