Changes in the gut microbiome can predict and decrease Epstein‐Barr virus infection risk in children after liver transplantation-Reference-Cited by-同舟云学术

Changes in the gut microbiome can predict and decrease Epstein‐Barr virus infection risk in children after liver transplantation

Published:2023-08-28 Issue:6 Volume:25 Page:
ISSN:1398-2273
Container-title:Transplant Infectious Disease
language:en
Short-container-title:Transplant Infectious Dis

Author:

Wang Xu¹^ORCID,Sun Liying²,Li Peng¹,Zhang Shutian¹

Affiliation:

1. Department of Gastroenterology Beijing Friendship Hospital, Capital Medical University Beijing P. R. China

2. Department of Liver Transplantation Beijing Friendship Hospital, Capital Medical University Beijing P. R. China

Abstract

AbstractObjectivePrimary Epstein‐Barr virus (EBV) infection is observed in 60% of children during the first year after liver transplantation as usage of imm‐unosuppressant. Finding predictive indicators of EBV infection is important to reduce the morbidity and mortality of EBV infection‐related diseases by suggesting a dose reduction of immunosuppressant.MethodsWe compared and analysed the gut microbiome of EBV‐infected children with an asymptomatic virus‐carrying status and EBV‐uninfected children after liver transplantation using high‐throughput sequencing.ResultsSignificant differences in gut microbiome composition in two groups were detected. In detail, Firmicutes and Lactobacillus were increased in EBV‐infected group, while Clostridium was increased in EBV‐uninfected group. Furthermore, CD4 percentage in T cells of blood showed a significant positive correlation with the content of Clostridium sp. CAG: 127 in EBV‐uninfected group.ConclusionChanges in the gut microbiome could predict and decrease the EBV infection risk of children after liver transplantation.

image

Publisher

Wiley

Subject

Infectious Diseases,Transplantation

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/tid.14114

Reference17 articles.

1. Lymphoproliferative Disorders After Solid Organ Transplantation—Classification, Incidence, Risk Factors, Early Detection and Treatment Options

2. Epstein-Barr virus DNA monitoring in serum and whole blood in pediatric liver transplant recipients who do or do not discontinue immunosuppressive therapy

3. Posttransplant Lymphoproliferative Disease after Pediatric Solid Organ Transplantation

4. The Intestinal Microbiome in Early Life: Health and Disease

5. Role of the gut microbiota in immunity and inflammatory disease