Lean body weight dosing avoids excessive systemic exposure to proton pump inhibitors for children with obesity

Author:

Shakhnovich V.123ORCID,Abdel-Rahman S.12,Friesen C. A.13,Weigel J.1,Pearce R. E.1,Gaedigk A.1,Leeder J. S.12,Kearns G. L.4

Affiliation:

1. Department of Pediatrics; University of Missouri Kansas City School of Medicine; Kansas City MO USA

2. Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation; The Childrens Mercy Hospital; Kansas City MO USA

3. Division of Gastroenterology, Hepatology and Nutrition; The Childrens Mercy Hospital; Kansas City MO USA

4. Section of Clinical Pharmacology and Toxicology; Arkansas Childrens Hospital; Little Rock AR USA

Funder

National Institute of Child Health and Human Development

Eunice Kennedy Shriver National Institute of Child Health and Human Development Pediatric Trials Network

The Children's Mercy Hospital

Childrens Mercy Hospital Fellowship Program in Pediatric Pharmacology

Publisher

Wiley

Subject

Public Health, Environmental and Occupational Health,Nutrition and Dietetics,Health Policy,Pediatrics, Perinatology, and Child Health

Reference9 articles.

1. Prevalence of childhood and adult obesity in the United States;Ogden;JAMA Pediatr,2013

2. Extreme childhood obesity is associated with increased risk for gastroesophageal reflux disease in a large population-based study;Koebnick;Int J Pediatr Obes,2011

3. Gastroesophageal reflux disease: could intervention in childhood reduce the risk of later complications?;Gold;Am J Med,2004

4. Obese children require lower doses of pantoprazole than nonobese peers to achieve equal systemic drug exposures;Shakhnovich;J Pediatr,2018

5. Side effects and complications of proton pump inhibitors: a pediatric perspective;Stark;J Pediatr,2016

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