Drug effects on the CVS in conscious rats: separating cardiac output into heart rate and stroke volume using PKPD modelling

Author:

Snelder N1,Ploeger B A1,Luttringer O2,Rigel D F3,Fu F3,Beil M3,Stanski D R2,Danhof M1

Affiliation:

1. Division of Pharmacology; Leiden Academic Centre for Drug Research; Gorlaeus Laboratories; Leiden The Netherlands

2. Modeling and Simulation Department; Novartis; Basel Switzerland

3. Cardiovascular and Metabolism Research; Novartis Institutes for BioMedical Research; Novartis Pharmaceuticals Corporation; East Hanover NJ USA

Funder

Novartis

Publisher

Wiley

Subject

Pharmacology

Reference43 articles.

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4. Effect of aging on the pharmacokinetics of atenolol, metoprolol and propranolol in the rat;Belpaire;J Pharmacol Exp Ther,1990

5. Strategies to prevent and treat cardiovascular risk in cancer patients;Cardinale;Semin Oncol,2013

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