Hyperglycemia Increases the Production of Amyloid Beta-Peptide Leading to Decreased Endothelial Tight Junction

Author:

Chao A-Ching1,Lee Tai-Chi2,Juo Suh-Hang Hank2,Yang Ding-I3

Affiliation:

1. Department of Neurology; College of Medicine; Kaohsiung Medical University and Hospital; Kaohsiung Taiwan Republic of China

2. Department of Genome Medicine; Kaohsiung Medical University; Kaohsiung Taiwan Republic of China

3. Institute of Brain Science; National Yang-Ming University; Taipei Taiwan Republic of China

Funder

Ministry of Science and Technology

Kaohsiung Medical University

Publisher

Wiley

Subject

Pharmacology (medical),Physiology (medical),Psychiatry and Mental health,Pharmacology

Reference27 articles.

1. Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks;Palop;Nat Neurosci,2010

2. Cerebral amyloid angiopathy impact on endothelium;Grinberg;Exp Gerontol,2012

3. Blood-brain barrier permeability precedes senile plaque formation in an Alzheimer disease model;Ujiie;Microcirculation,2003

4. Endothelial dysfu-nction in diabetes mellitus: possible involvement of endop-lasmic reticulum stress?;Basha;Exp Diabetes Res,2012

5. Endothelial dysfunction in (pre)diabetes: characteristics, causative mechanisms and pathogenic role in type 2 diabetes;Eringa;Rev Endocr Metab Disord,2013

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