Asp68His mutation in the A1 domain of human factor V causes impaired secretion and ineffective translocation

Author:

Liu H.-C.12,Shen M.-C.3,Eng H.-L.4,Wang C.-H.5,Lin T.-M.152

Affiliation:

1. Institute of Basic Medical Sciences; National Cheng Kung University; Tainan Taiwan

2. Department of Medical Research; E-DA Hospital/I-SHOU University; Kaohsiung Taiwan

3. Hemophilia Treatment and Thrombosis Center; Changhua Christian Hospital; Changhua Taiwan

4. Department of Pathology; Kaohsiung Chang Gung Memorial Hospital; Chang Gung University College of Medicine; Kaohsiung Taiwan

5. Department of Laboratory Medicine; E-DA Hospital/I-SHOU University; Kaohsiung Taiwan

Funder

Taiwan National Science Council

Publisher

Wiley

Subject

Genetics(clinical),Hematology,General Medicine

Reference39 articles.

1. Blood coagulation factors V and VIII: structural and functional similarities and their relationship to hemorrhagic and thrombotic disorders;Kane;Blood,1988

2. Structure of the gene for human coagulation factor V;Cripe;Biochemistry,1992

3. Complete cDNA and derived amino acid sequence of human factor V;Jenny;Proc Natl Acad Sci U S A,1987

4. Formation of a calcium-binding site on bovine activated factor V following recombination of the isolated subunits;Guinto;J Biol Chem,1982

5. The crystal structure of activated protein C-inactivated bovine factor Va: implications for cofactor function;Adams;Proc Natl Acad Sci U S A,2004

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