TRPM8 indicates poor prognosis in colorectal cancer patients and its pharmacological targeting reduces tumour growth in mice by inhibiting Wnt/β‐catenin signalling

Author:

Pagano Ester1,Romano Barbara1,Cicia Donatella1,Iannotti Fabio A.2ORCID,Venneri Tommaso1,Lucariello Giuseppe1,Nanì Maria Francesca1,Cattaneo Fabio3,De Cicco Paola1,D'Armiento Maria4,De Luca Marcello4,Lionetti Ruggiero4,Lama Stefania5,Stiuso Paola5,Zoppoli Pietro6,Falco Geppino78,Marchianò Silvia9,Fiorucci Stefano9ORCID,Capasso Raffaele10,Di Marzo Vincenzo2111213,Borrelli Francesca1,Izzo Angelo A.1

Affiliation:

1. Department of Pharmacy, School of Medicine and Surgery University of Naples Federico II Naples Italy

2. Institute of Biomolecular Chemistry ICB, CNR Pozzuoli, Naples Italy

3. Department of Molecular Medicine and Medical Biotechnology, School of Medicine and Surgery University of Naples Federico II Naples Italy

4. Department of Public Health, School of Medicine and Surgery University of Naples Federico II Naples Italy

5. Department of Precision Medicine University of Campania Luigi Vanvitelli Naples Italy

6. Laboratory of Pre‐Clinical and Translational Research IRCCS, Referral Cancer Center of Basilicata Rionero in Vulture Italy

7. Istituto di Ricerche Genetiche Gaetano Salvatore Biogem Scarl Ariano Irpino Italy

8. Department of Biology University of Naples Federico II Naples Italy

9. Department of Medicine and Surgery University of Perugia Perugia Italy

10. Department of Agricultural Sciences University of Naples Federico II Naples Italy

11. Institut sur la Nutrition et les Aliments Fonctionnels, Centre NUTRISS, École de nutrition, Faculté des sciences de l'agriculture et de l'alimentation (FSAA) Université Laval Québec Canada

12. Centre de Recherche de l'Institut de Pneumologie et Cardiologie de l'Université Laval, Faculté de Médecine Université Laval Québec Canada

13. Canada Research Excellence Chair on the Microbiome‐Endocannabinoidome Axis in Metabolic Health (CERC‐MEND) Université Laval Québec Canada

Funder

Ministero dell'Università e della Ricerca

Regione Campania

Publisher

Wiley

Subject

Pharmacology

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