The Concise Guide to PHARMACOLOGY 2023/24: Transporters

Author:

Alexander Stephen P. H.1ORCID,Fabbro Doriano2ORCID,Kelly Eamonn3,Mathie Alistair A.4ORCID,Peters John A.5ORCID,Veale Emma L.4ORCID,Armstrong Jane F.6ORCID,Faccenda Elena6ORCID,Harding Simon D.6ORCID,Davies Jamie A.6ORCID,Amarosi Laura7,Anderson Catriona M. H.8ORCID,Beart Philip M.9ORCID,Broer Stefan10ORCID,Dawson Paul A.11ORCID,Gyimesi Gergely12ORCID,Hagenbuch Bruno13ORCID,Hammond James R.14ORCID,Hancox Jules C.15ORCID,Hershfinkel Michal16ORCID,Inui Ken‐ichi17ORCID,Kanai Yoshikatsu18,Kemp Stephan19ORCID,Kunji Edmund R. S.20ORCID,Stewart Gavin21ORCID,Tavoulari Sotiria20ORCID,Thwaites David T.8ORCID,Verri Tiziano7ORCID

Affiliation:

1. School of Life Sciences University of Nottingham Medical School Nottingham NG7 2UH UK

2. PIQUR Therapeutics Basel 4057 Switzerland

3. School of Physiology, Pharmacology and Neuroscience University of Bristol Bristol BS8 1TD UK

4. School of Allied Health Sciences University of Suffolk Ipswich IP4 1QJ UK

5. Neuroscience Division, Medical Education Institute, Ninewells Hospital and Medical School University of Dundee Dundee DD1 9SY UK

6. Centre for Discovery Brain Sciences University of Edinburgh Edinburgh EH8 9XD UK

7. University of Salento Lecce Italy

8. Newcastle University Newcastle upon Tyne UK

9. Florey Institute of Neuroscience and Mental Health Melbourne Australia

10. Australian National University Canberra Australia

11. Emory University Atlanta USA

12. University of Bern Bern Switzerland

13. University of Kansas Kansas City USA

14. University of Alberta Edmonton Canada

15. University of Bristol Bristol UK

16. Ben‐Gurion University of the Negev Beer Sheva Israel

17. Kyoto Pharmaceutical University Kyoto Japan

18. Osaka University Osaka Japan

19. Amsterdam University Amsterdam The Netherlands

20. University of Cambridge Cambridge UK

21. University College Dublin Dublin Ireland

Abstract

The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (https://www.guidetopharmacology.org/), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point‐in‐time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.16182. Transporters are one of the six major pharmacological targets into which the Guide is divided, with the others being: G protein‐coupled receptors, ion channels, nuclear hormone receptors, catalytic receptors and enzymes. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid‐2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC‐IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

Publisher

Wiley

Subject

Pharmacology

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