Hormonal and pheromonal studies on amphibians with special reference to metamorphosis and reproductive behavior

Abstract

AbstractIn this article, we review studies which have been conducted to investigate the hormonal influence on metamorphosis in bullfrog (Rana catesbeiana) and Japanese toad (Bufo japonicus) larvae, in addition to studies conducted on the hormonal and pheromonal control of reproductive behavior in red‐bellied newts (Cynops pyrrhogaster). Metamorphosis was studied with an emphasis on the roles of prolactin (PRL) and thyrotropin (TSH). The release of PRL was shown to be regulated by thyrotropin‐releasing hormone (TRH) and that of TSH was evidenced to be regulated by corticotropin‐releasing factor. The significance of the fact that the neuropeptide that controls the secretion of TSH is different from those encountered in mammals is discussed in consideration of the observation that the release of TRH, which stimulates the release of PRL, is enhanced when the animals are subjected to a cold temperature. Findings that were made by using melanin‐rich cells of Bufo embryos and larvae, such as the determination of the origin of the adenohypophyseal primordium, identification of the pancreatic chitinase, and involvement of the rostral preoptic recess organ as the hypothalamic inhibitory center of α‐melanocyte‐stimulating hormone (α‐MSH) secretion, are mentioned in this article. In addition, the involvement of hormones in eliciting courtship behavior in male red‐bellied newts and the discovery of the peptide sex pheromones and hormonal control of their secretion are also discussed in the present article.