First‐in‐human phase I study of infusional and bolus schedules of Deflexifol, a novel 5‐fluorouracil and leucovorin formulation, after failure of standard treatment

Author:

Clingan Philip R.12,Ackland Stephen P.3ORCID,Brungs Daniel24,Souza Paul5,Aghmesheh Morteza26,Garg Madhu B.3,Ranson Richard D.7ORCID,Parker Suzanne1,Jokela Rebecca1,Ranson Marie24ORCID

Affiliation:

1. Southern Medical Day Care Centre Wollongong Australia

2. Illawarra Health and Medical Research Institute Wollongong Australia

3. Calvary Mater Hospital/ HMRI Newcastle Australia

4. School of Chemistry and Molecular BioscienceUniversity of Wollongong Wollongong Australia

5. Western Sydney University School of Medicine Sydney Australia

6. Illawarra Cancer Care Centre Wollongong Australia

7. FivepHusion Pty Ltd. Austinmer NSW Australia

Funder

Fivephusion Pty Ltd

Publisher

Wiley

Subject

Oncology,General Medicine

Reference28 articles.

1. Cancer Institute NSW:EviQ Cancer Treatments Online: Medical Oncology.https://www.eviq.org.au/. Accessed June 4 2018.

2. A new complication of chemotherapy administered via permanent indwelling central venous catheter

3. Catheter occlusion by calcium carbonate during simultaneous infusion of 5‐FU and calcium folinate;Bruch HR;Onkologie,2003

4. Development and assessment of novel all-in-one parenteral formulations with integrated anticoagulant properties for the concomitant delivery of 5-fluorouracil and calcium folinate

5. Stability of fluorouracil administered through four portable infusion pumps;Stiles ML;Am J Hosp Pharm,1989

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