<scp>ERS</scp>: A simple scoring system to predict early recurrence after surgical resection for hepatocellular carcinoma-Reference-Cited by-同舟云学术

ERS: A simple scoring system to predict early recurrence after surgical resection for hepatocellular carcinoma

Published:2023-08-14 Issue:11 Volume:43 Page:2538-2547
ISSN:1478-3223
Container-title:Liver International
language:en
Short-container-title:Liver International

Author:

Costentin Charlotte¹^ORCID,Audureau Etienne²,Park Young Nyun³^ORCID,Langella Serena⁴,Vibert Eric⁵,Laurent Alexis⁶,Cauchy François⁷,Scatton Olivier⁸,Chirica Mircea⁹,Rhaiem Rami¹⁰,Boleslawski Emmanuel¹¹,di Tommaso Luca¹²¹³,Ferrero Alessandro⁴,Yano Hirohisa¹⁴,Akiba Jun¹⁵,Donadon Matteo¹³¹⁶,Nebbia Martina¹⁷,Detry Olivier¹⁸,Honoré Pierre¹⁸,Di Martino Marcello¹⁹,Schwarz Lilian²⁰,Barbier Louise²¹^ORCID,Nault Jean‐Charles²²²³^ORCID,Rhee Hyungjin²⁴,Lim Chetana⁸,Brustia Raffaele⁶,Paradis Valérie²⁵^ORCID,Guettier Catherine²⁶,Le Bail Brigitte²⁷,Okumura Shinya²⁸,Blanc Jean‐Frédéric²⁹,Calderaro Julien³⁰

Affiliation:

1. Grenoble Alpes University, Institute for Advanced Biosciences, Research Center UGA/Inserm U 1209/CNRS 5309, Gastroenterology, Hepatology and GI Oncology Department, Digidune, Grenoble Alpes University Hospital La Tronche France

2. Service de Santé Publique Assistance Publique Hôpitaux de Paris, Hôpital Henri Mondor, and Université Paris‐Est, A‐TVB DHU, CEpiA (Clinical Epidemiology and Ageing) Unit EA7376, UPEC Créteil France

3. Department of Pathology, Graduate School of Medical Science, Brain Korea 21 Project Yonsei University College of Medicine Seoul Republic of Korea

4. Department of General and Oncological Surgery Ospedale Mauriziano “Umberto I” Turin Italy

5. Centre hépato‐biliaire Assistance Publique Hôpitaux de Paris, Hôpital Paul Brousse Villejuif France

6. Service de Chirurgie Digestive Assistance Publique Hôpitaux de Paris, Groupe Hospitalier Henri Mondor Créteil France

7. Service de Chirurgie Hepato‐Bilio‐Pancréatique et Transplantation Hépatique Hôpital Beaujon, AP‐HP et Université de Paris Clichy France

8. Service de Chirurgie Digestive Assistance Publique Hôpitaux de Paris, Groupe Hospitalier Pitié Salpétrière Paris France

9. Service de Chirurgie Digestive CHU Grenoble‐Alpes Grenoble France

10. Service de Chirurgie Digestive CHU de Reims Reims France

11. Univ. Lille, INSERM U1189, CHU Lille, Service de Chirurgie Digestive et Transplantations Lille France

12. Unit of Pathology IRCCS Humanitas Research Hospital Rozzano, Milan Italy

13. Department of Biomedical Sciences Humanitas University Pieve Emanuele, Milan Italy

14. Department of Pathology Kurume University School of Medicine Kurume Japan

15. Department of Diagnostic Pathology Kurume University Hospital Kurume Japan

16. Department of Hepatobiliary and General Surgery Humanitas Clinical and Research Center – IRCCS Rozzano Italy

17. Department of Surgery, Colon and Rectal Surgery Unit IRCCS Humanitas Research Hospital Rozzano, Milan Italy

18. Department of Abdominal Surgery and Transplantation Centre Hospitalier Universitaire de Liege, University of Liege Liege Belgium

19. Department of Surgery, HPB Unit University Hospital La Princesa Madrid Spain

20. Service de Chirurgie Digestive CHU de Rouen Rouen France

21. Service de Chirurgie Digestive CHU de Tours Tours France

22. Liver Unit Hôpital Avicenne, Hôpitaux Universitaires Paris‐Seine‐Saint‐Denis, Assistance‐Publique Hôpitaux de Paris, Unité de Formation et de Recherche Santé Médecine et Biologie Humaine, Université Paris 13, Communauté d’Universités et Etablissements Sorbonne Paris Cité Bobigny France

23. Centre de Recherche des Cordeliers Sorbonne Université, Inserm, Université de Paris, team « Functional Genomics of Solid Tumors », Equipe labellisée Ligue Nationale Contre le Cancer, Labex OncoImmunology Paris France

24. Department of Radiology Research Institute of Radiological Science, Center for Clinical Imaging Data Science, Severance Hospital, Yonsei University College of Medicine Seoul Republic of Korea

25. Service d’Anatomie et de Cytologie Pathologique Assistance Publique Hôpitaux de Paris, Hôpital Beaujon, Université de Paris Clichy France

26. Service d’Anatomie et de Cytologie Pathologique Assistance Publique Hôpitaux de Paris, Hôpital Bicêtre Le Kremlin‐Bicêtre France

27. Service de Pathologie Hôpital Pellegrin, Centre Hospitalier Universitaire de Bordeaux Bordeaux France

28. Division of Hepato‐Biliary‐Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine Kyoto University Kyoto Japan

29. Service Hépato‐Gastroentérologie et Oncologie Digestive Centre Médico‐Chirurgical Magellan, Hôpital Haut‐Lévêque, Centre Hospitalier Universitaire de Bordeaux Bordeaux France

30. Département de Pathologie Assistance Publique Hôpitaux de Paris, Groupe Hospitalier Henri Mondor Créteil France

Abstract

AbstractBackgroundSurgical resection (SR) is a potentially curative treatment of hepatocellular carcinoma (HCC) hampered by high rates of recurrence. New drugs are tested in the adjuvant setting, but standardised risk stratification tools of HCC recurrence are lacking.ObjectivesTo develop and validate a simple scoring system to predict 2‐year recurrence after SR for HCC.Methods2359 treatment‐naïve patients who underwent SR for HCC in 17 centres in Europe and Asia between 2004 and 2017 were divided into a development (DS; n = 1558) and validation set (VS; n = 801) by random sampling of participating centres. The Early Recurrence Score (ERS) was generated using variables associated with 2‐year recurrence in the DS and validated in the VS.ResultsVariables associated with 2‐year recurrence in the DS were (with associated points) alpha‐fetoprotein (<10 ng/mL:0; 10–100: 2; >100: 3), size of largest nodule (≥40 mm: 1), multifocality (yes: 2), satellite nodules (yes: 2), vascular invasion (yes: 1) and surgical margin (positive R1: 2). The sum of points provided a score ranging from 0 to 11, allowing stratification into four levels of 2‐year recurrence risk (Wolbers' C‐indices 66.8% DS and 68.4% VS), with excellent calibration according to risk categories. Wolber's and Harrell's C‐indices apparent values were systematically higher for ERS when compared to Early Recurrence After Surgery for Liver tumour post‐operative model to predict time to early recurrence or recurrence‐free survival.ConclusionsERS is a user‐friendly staging system identifying four levels of early recurrence risk after SR and a robust tool to design personalised surveillance strategies and adjuvant therapy trials.

Publisher

Wiley

Subject

Hepatology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/liv.15683

Reference42 articles.

1. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

2. Epidemiology of Hepatocellular Carcinoma

3. Salvage Liver Transplant versus Primary Liver Transplant for Patients with Hepatocellular Carcinoma

4. EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma

5. Extended Hepatic Resection for Hepatocellular Carcinoma in Patients with Cirrhosis: Is It Justified?

Cited by 9 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A simple model to predict early recurrence of hepatocellular carcinoma after liver resection;Langenbeck's Archives of Surgery;2024-08-23

2. Association between Pre-operative Body Mass Index and Surgical Infection in Perihilar Cholangiocarcinoma Patients Treated with Curative Resection: A Multi-center Study;Surgical Infections;2024-08-01

3. Letter to the editor: ‘A simple scoring system to predict early recurrence after surgical resection for hepatocellular carcinoma’;Liver International;2024-07-16

4. First‐line treatment of BCLC 0‐A HCC transplantable patients: The era of minimally invasive techniques;Liver International;2024-05-22

5. Beyond histology: A tissue algorithm predictive of post-surgical recurrence in hepatocellular carcinomas, including TERT promoter mutation;Virchows Archiv;2024-05-18