Major mixed motility disorders: An important subset of esophagogastric junction outflow obstruction

Author:

Leopold Andrew R.1ORCID,Jalalian Aria2,Thaker Parth3,Wellington Jennifer14,Papademetriou Marianna5,Xie Guofeng16ORCID

Affiliation:

1. Division of Gastroenterology and Hepatology, Department of Medicine University of Maryland School of Medicine Baltimore Maryland USA

2. University of Maryland School of Medicine Baltimore Maryland USA

3. Department of Internal Medicine University of Maryland School of Medicine Baltimore Maryland USA

4. Atrium Health Gastroenterology and Hepatology Charlotte North Carolina USA

5. Division of Gastroenterology and Hepatology Veterans Affairs Washington DC Medical Center Washington D.C. USA

6. Division of Gastroenterology and Hepatology Veterans Affairs Maryland Healthcare System Baltimore Maryland USA

Abstract

AbstractBackgroundEsophagogastric junction outflow obstruction (EGJOO) is an esophageal motility disorder characterized by a lack of relaxation of the esophagogastric junction (EGJ), with preserved esophageal body peristalsis. We propose new terminology for the coexistence of EGJOO with hypercontractile esophagus and distal esophageal spasm as a major mixed motility disorder (MMMD), and normal peristalsis or a minor disorder of peristalsis such as ineffective esophageal motility with EGJOO as isolated or ineffective EGJOO (IEGJOO).MethodsWe reviewed prior diagnoses of EGJOO, stratified diagnoses as IEGJOO or MMMD, and compared their symptomatic presentations, high‐resolution manometry (HRM) and endoluminal functional lumen imaging probe (EndoFLIP) metrics, and treatment responses at 2–6 months of follow‐up.ResultsOut of a total of 821 patients, 142 met CCv3 criteria for EGJOO. Twenty‐two were confirmed by CCv4 and EndoFLIP as having EGJOO and were clinically managed. Thirteen had MMMD, and nine had IEGJOO. Groups had no difference in demographic data or presenting symptoms by Eckardt score (ES). HRM showed MMMD had greater distal contractile integral, frequency of hypercontractile swallows, and frequency of spastic swallows, and greater DI by EndoFLIP. Patients with MMMD showed greater reduction in symptoms after LES‐directed intervention when measured by ES compared with IEGJOO (7.2 vs. 4.0).ConclusionPatients with MMMD and IEGJOO present similarly. Detectable differences in HRM portend different responses to endoscopic therapy. Because patients with MMMD have greater short‐term prognosis, they should be considered a different diagnostic classification to guide therapy.

Funder

National Institutes of Health

Publisher

Wiley

Subject

Gastroenterology,Endocrine and Autonomic Systems,Physiology

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