Characteristics of metabolic stability and the cell permeability of 2‐pyrimidinyl‐piperazinyl‐alkyl derivatives of 1H‐imidazo[2,1 ‐f ]purine‐2,4(3 H ,8 H )‐dione with antidepressant‐ and anxiolytic‐like activities-Reference-Cited by-同舟云学术

Characteristics of metabolic stability and the cell permeability of 2‐pyrimidinyl‐piperazinyl‐alkyl derivatives of 1H‐imidazo[2,1 ‐f ]purine‐2,4(3 H ,8 H )‐dione with antidepressant‐ and anxiolytic‐like activities

Published:2018-12-04 Issue:4 Volume:93 Page:511-521
ISSN:1747-0277
Container-title:Chemical Biology & Drug Design
language:en
Short-container-title:Chem Biol Drug Des

Author:

Zagórska Agnieszka¹^ORCID,Partyka Anna²,Bucki Adam¹,Kołaczkowski Marcin¹,Jastrzębska‐Więsek Magdalena²,Czopek Anna¹,Siwek Agata³,Głuch‐Lutwin Monika⁴,Bednarski Marek⁴,Bajda Marek⁵,Jończyk Jakub⁵,Piska Kamil⁶,Koczurkiewicz Paulina⁶,Wesołowska Anna²,Pawłowski Maciej¹

Affiliation:

1. Department of Medicinal ChemistryJagiellonian University Medical College Kraków Poland

2. Department of Clinical PharmacyJagiellonian University Medical College Kraków Poland

3. Department of PharmacobiologyJagiellonian University Medical College Kraków Poland

4. Department of PharmacodynamicsJagiellonian University Medical College Kraków Poland

5. Department of Physicochemical Drug AnalysisJagiellonian University Medical College Kraków Poland

6. Department of Pharmaceutical BiochemistryJagiellonian University Medical College Kraków Poland

Funder

Narodowe Centrum Nauki

Uniwersytet Jagielloński Collegium Medicum

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/cbdd.13442

Reference50 articles.

1. Novel benzodioxan derivative, 5‐[3‐[((2S)‐1,4‐benzodioxan‐2‐ylmethyl) amino]propoxy]‐1,3‐benzodioxole HCl (MKC‐242), with anxiolytic‐like and antidepressant‐like effects in animal models;Abe M.;Journal of Pharmacology and Experimental Therapeutics,1996

2. The neurobiology of depression—revisiting the serotonin hypothesis. II. Genetic, epigenetic and clinical studies

3. Evaluation of a rapid technique for detecting minor tranquilizers

4. Novel 3-(1,2,3,6-Tetrahydropyridin-4-yl)-1H-indole-Based Multifunctional Ligands with Antipsychotic-Like, Mood-Modulating, and Procognitive Activity

5. Solid-supported synthesis, molecular modeling, and biological activity of long-chain arylpiperazine derivatives with cyclic amino acid amide fragments as 5-HT7 and 5-HT1A receptor ligands

Cited by 9 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Neuropharmacological Potential of Different Piperazine Analogs: A Recent Prospective;Mini-Reviews in Organic Chemistry;2024-01-16

2. PDE4 inhibitors for disease therapy: advances and future perspective;Future Medicinal Chemistry;2023-07

3. A Review on the Arylpiperazine Derivatives as Potential Therapeutics for the Treatment of Various Neurological Disorders;Current Drug Targets;2022-07

4. Recent Advances in the Biological Significance of Xanthine and its Derivatives: A Review;Pharmaceutical Chemistry Journal;2022-07

5. A comprehensive review on pyrimidine analogs-versatile scaffold with medicinal and biological potential;Journal of Molecular Structure;2021-12