Novel Ti surface coated with PVA hydrogel and chitosan nanoparticles with antibacterial drug release: An experimental in vitro study

Author:

Carrazco Ávila Pablo Yael1ORCID,Arias Moliz Teresa2,Rosales Leal Juan Ignacio1ORCID,Baca Pilar1,Rodríguez Valverde Miguel Ángel3,Morales Hernandez María Encarnación4

Affiliation:

1. Department of Stomatology, School of Dentistry, Campus de Cartuja s/n University of Granada Granada Spain

2. Department of Microbiology, School of Dentistry University of Granada Granada Spain

3. Department of applied Physics, School of Science University of Granada Granada Spain

4. Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, Campus de Cartuja s.n. University of Granada Granada Spain

Abstract

AbstractObjectivesThe aims of this study were to design a novel titanium surface coated with a PVA hydrogel matrix and chitosan‐based nanoparticles and to investigate the antibiotic release and its ability to inhibit microbial activity.MethodsTwo drug delivery systems were developed and mixed. Chitosan‐based nanoparticles (NP) and a polyvinyl alcohol film (PVA). The size, ζ‐potential, stability, adhesive properties, and encapsulation profile of NP, as well as the release kinetics of drug delivery systems and their antimicrobial ability of PVA and PVANP films, were studied on Ti surfaces. The systems were loaded with doxycycline, vancomycin, and doxepin hydrochloride.ResultsNanoparticles presented a ζ‐potential greater than 30 mV for 45 days and the efficiency drug encapsulation was 26.88% ± 1.51% for doxycycline, 16.09% ± 10.24% for vancomycin and 17.57% ± 11.08% for doxepin. In addition, PVA films were loaded with 125 μg/mL of doxycycline, 125 μg/mL of vancomycin, and 100 μg/mL of doxepin. PVANP‐doxycycline achieved the antibacterial effect at 4 h while PVA‐doxycycline maintained its effect at 24 h.

Publisher

Wiley

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