Effective removal of gadolinium with hemodialysis in a dog with severe acute on chronic kidney injury

Abstract

AbstractObjectiveTo describe the use of intermittent hemodialysis (IHD) to remove gadolinium (28.1 mg/kg dose) in a dog with severe kidney disease.Case SummaryA 12‐year‐old neutered female Yorkshire Terrier presented with severe acute‐on‐chronic kidney injury and concurrent neurological signs. The dog received extracorporeal therapy as part of management. Uremia improved after hemodialysis, but central nervous system signs persisted; therefore, a contrast‐enhanced magnetic resonance imaging was performed, immediately followed by IHD. Two IHD treatments with a low‐flux dialyzer were performed 1.5 and 25.75 hours after administration of gadolinium, with almost complete removal of gadolinium. More than 96% of gadolinium was removed with a single treatment.New or Unique Information ProvidedExtracorporeal therapy is effective at removing gadolinium‐based chelated contrast agents and could be considered if magnetic resonance imaging is indicated in a patient with substantial kidney impairment. Alternatively, newer contrast agents that have been deemed safer in this patient population could be used.