Aluminum hydroxide adjuvant diverts the uptake and trafficking of genetically detoxified pertussis toxin to lysosomes in macrophages-Reference-Cited by-同舟云学术

Aluminum hydroxide adjuvant diverts the uptake and trafficking of genetically detoxified pertussis toxin to lysosomes in macrophages

Published:2022-04-07 Issue:5 Volume:117 Page:1173-1195
ISSN:0950-382X
Container-title:Molecular Microbiology
language:en
Short-container-title:Molecular Microbiology

Author:

Jaldin‐Fincati Javier R.¹^ORCID,Moussaoui Serene¹²,Gimenez Maria Cecilia¹,Ho Cheuk Y.¹,Lancaster Charlene E.¹²^ORCID,Botelho Roberto J.³,Ausar Salvador F.⁴^ORCID,Brookes Roger H.⁴,Terebiznik Mauricio R.¹²^ORCID

Affiliation:

1. Department of Biological Sciences University of Toronto at Scarborough Toronto Ontario Canada

2. Department of Cell and Systems Biology University of Toronto at Scarborough Toronto Ontario Canada

3. Department of Chemistry and Biology Ryerson University Toronto Ontario Canada

4. BioProcess Research and Development Sanofi Pasteur Ltd. Toronto Ontario Canada

Funder

Mitacs

Natural Sciences and Engineering Research Council of Canada

Ryerson University

University of Toronto

Publisher

Wiley

Subject

Molecular Biology,Microbiology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/mmi.14900

Reference78 articles.

1. Myosin IIA and formin dependent mechanosensitivity of filopodia adhesion

2. A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages.

3. Genetically detoxified pertussis toxin displays near identical structure to its wild-type and exhibits robust immunogenicity

4. Mechanisms of Action of Adjuvants

5. Thermal Unfolding of the Pertussis Toxin S1 Subunit Facilitates Toxin Translocation to the Cytosol by the Mechanism of Endoplasmic Reticulum-Associated Degradation

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