Tetrahedral framework nucleic acid nanomaterials reduce the inflammatory damage in sepsis by inhibiting pyroptosis

Author:

Chen Xingyu1,He Jiajun1,Xie Yu1,Zhang Tianxu1,Li Songhang1,Zhao Yuxuan1,Hu Nan2,Cai Xiaoxiao1ORCID

Affiliation:

1. State Key laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology Sichuan University Chengdu China

2. Department of Stomatology First Medical Center, Chinese PLA General Hospital Beijng China

Abstract

AbstractSepsis is a highly lethal condition and is caused by the dysregulation of the body's immune response to infection. Indeed, sepsis remains the leading cause of death in severely ill patients, and currently, no effective treatment is available. Pyroptosis, which is mainly activated by cytoplasmic danger signals and eventually promote the release of the pro‐inflammatory factors, is a newly discovered programmed cell death procedure that clears infected cells while simultaneously triggering an inflammatory response. Increasing evidence indicates that pyroptosis participates in the development of sepsis. As a novel DNA nanomaterial, tetrahedral framework nucleic acids (tFNAs) characterized by its unique spatial structure, possess an excellent biosafety profile and can quickly enter the cell to impart anti‐inflammatory and anti‐oxidation effects. In this study, the roles of tFNAs in the in vitro model of macrophage cell pyroptosis and in the in vivo model of septic mice were examined, and it was found that tFNAs could mitigate organ inflammatory damage in septic mice, wherein they reduced inflammatory factor levels by inhibiting pyroptosis. These results provide possible new strategies for the future treatment of sepsis.

Funder

National Natural Science Foundation of China

Sichuan Province Youth Science and Technology Innovation Team

Publisher

Wiley

Subject

Cell Biology,General Medicine

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