A comprehensive diagnostic approach using galactomannan, targeted β-d-glucan, baseline computerized tomography and biopsy yields a significant burden of invasive fungal disease in at risk haematology patients

Author:

Ceesay M. Mansour1,Desai Sujal R.2,Berry Lisa3,Cleverley Joanne4,Kibbler Christopher C.5,Pomplun Sabine6,Nicholson Andrew G.7,Douiri Abdel8,Wade Jim9,Smith Melvyn3,Mufti Ghulam J.1,Pagliuca Antonio1

Affiliation:

1. Department of Haematological Medicine; King's College Hospital NHS Foundation Trust; London UK

2. Department of Radiology; King's College Hospital NHS Foundation Trust; London UK

3. Department of Virology; King's College Hospital NHS Foundation Trust; London UK

4. Department of Radiology; Royal Free London NHS Foundation Trust; London UK

5. Department of Medical Microbiology; Royal Free London NHS Foundation Trust; London UK

6. Department of Histopathology; King's College Hospital NHS Foundation Trust; London UK

7. Department of Histopathology; Royal Brompton Hospital and National Heart and Lung Institute; Imperial College; London UK

8. Department of Public Health Science; King's College London and NIHR Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust; London UK

9. Department of Microbiology; King's College Hospital NHS Foundation Trust; London UK

Funder

Gilead Sciences

Pfizer

Merck Sharp & Dohme Limited

Publisher

Wiley

Subject

Hematology

Reference41 articles.

1. ECIL-3 classical diagnostic procedures for the diagnosis of invasive fungal diseases in patients with leukaemia;Arendrup;Bone Marrow Transplantation,2012

2. The strategy for the diagnosis of invasive pulmonary aspergillosis should depend on both the underlying condition and the leukocyte count of patients with hematologic malignancies;Bergeron;Blood,2012

3. Early neutrophil recruitment and aggregation in the murine lung inhibit germination of Aspergillus fumigatus Conidia;Bonnett;Infection and Immunity,2006

4. Invasive fungal infections in patients with hematologic malignancies in a tertiary care cancer center: an autopsy study over a 15-year period (1989-2003);Chamilos;Haematologica,2006

5. Posaconazole vs. fluconazole or itraconazole prophylaxis in patients with neutropenia;Cornely;New England Journal of Medicine,2007

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