Relative bioavailability of bedaquiline tablets suspended in water: Implications for dosing in children

Author:

Svensson Elin M.12ORCID,du Bois Jeannine3,Kitshoff Rene3,de Jager Veronique R.3,Wiesner Lubbe4,Norman Jennifer4,Nachman Sharon5,Smith Betsy6,Diacon Andreas H.37,Hesseling Anneke C.8,Garcia-Prats Anthony J.8

Affiliation:

1. Department of Pharmaceutical Biosciences; Uppsala University; Uppsala Sweden

2. Department of Pharmacy, Radboud Institute for Health Sciences; Radboud University Medical Center; Nijmegen The Netherlands

3. TASK Applied Science; Cape Town South Africa

4. Division of Clinical Pharmacology, Department of Medicine; University of Cape Town; Cape Town South Africa

5. Department of Pediatrics; State University of New York Stony Brook; New York USA

6. Division of AIDS; National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesada USA

7. Division of Medical Physiology, Faculty of Medicine and Health Sciences; Stellenbosch University; South Africa

8. Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences; Stellenbosch University; Cape Town South Africa

Funder

National Institute of Allergy and Infectious Diseases

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference21 articles.

1. Bedaquiline (BQ)-containing regimen at the programmatic level for MDR-TB: preliminary results;Borisov;Eur Respir J,2017

2. A Diarylquinoline drug active on the ATP synthase of mycobacterium tuberculosis;Andries;Science,2005

3. Bedaquiline: a review of human pharmacokinetics and drug-drug interactions;Heeswijk;J Antimicrob Chemother,2014

4. FDA Center for drug evaluation and research. Application number 204384Orig1s000 https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/204384Orig1s000ClinPharmR.pdf

5. Model-based estimates of the effects of efavirenz on bedaquiline pharmacokinetics and suggested dose adjustments for patients coinfected with HIV and tuberculosis;Svensson;Antimicrob Agents Chemother,2013

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