Cold ischemia with selective anterogradein situpulmonary perfusion preserves gas exchange and mitochondrial homeostasis and curbs inflammation in an experimental model of donation after cardiac death

Author:

Pottecher Julien12,Santelmo Nicola3,Noll Eric12,Charles Anne-Laure24,Benahmed Malika5,Canuet Matthieu6,Frossard Nelly7,Namer Izzie J.58,Geny Bernard24,Massard Gilbert3,Diemunsch Pierre12

Affiliation:

1. Department of Anaesthesiology and Critical Care; Hautepierre Hospital; Strasbourg University Hospital; Strasbourg Cedex France

2. Fédération de Médecine Translationnelle de Strasbourg (FMTS); Faculty of Medicine; Physiology Institute; EA 3072; Strasbourg University; Strasbourg France

3. Department of Thoracic Surgery; Nouvel Hôpital Civil; Strasbourg University Hospital; Strasbourg France

4. Department of Physiology; Nouvel Hôpital Civil; Strasbourg University Hospital; Strasbourg France

5. ICube; UMR 7357 University of Strasbourg/CNRS; Strasbourg Cedex France

6. Department of Pneumology; Nouvel Hôpital Civil; Strasbourg University Hospital; FMTS, Faculty of Medicine, Strasbourg France

7. Faculty of Pharmacy; Strasbourg University/CNRS UMR 7200; Illkirch France

8. Department of Biophysics and Nuclear Medicine; Hautepierre Hospital; Strasbourg University Hospital; Strasbourg Cedex France

Funder

Agence de la Biomédecine (ABM)

Publisher

Frontiers Media SA

Subject

Transplantation

Reference43 articles.

1. Long term results of lung transplantation for cystic fibrosis;Egan;Eur J Cardiothorac Surg,2002

2. Lung transplantation in patients with cystic fibrosis;Morton;Semin Respir Crit Care Med,2009

3. Lung transplantation from donation after cardiac death (non-heart-beating) donors;Oto;Gen Thorac Cardiovasc Surg,2008

4. Categories of non-heart-beating donors;Kootstra;Transplant Proc,1995

5. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest;The Hyphothermia After Cardiac Arrest Study Group;N Engl J Med,2002

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