Multiple genetic alterations in vitamin K epoxide reductase complex subunit 1 gene (VKORC1) can explain the high dose requirement during oral anticoagulation in humans
Author:
Publisher
Wiley
Subject
Hematology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/j.1538-7836.2008.03049.x/fullpdf
Reference19 articles.
1. Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2;Rost;Nature,2004
2. A polymorphism in the VKORC1 gene is associated with an interindividual variability in the dose-anticoagulant effect of warfarin;DAndrea;Blood,2005
3. Cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genotypes as determinants of acenocoumarol sensitivity;Bodin;Blood,2005
4. Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose;Rieder;N Engl J Med,2005
5. The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements: proposal for a new dosing regimen;Sconce;Blood,2005
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1. VKORC1 polymorphisms and complete resistance to Vitamin K antagonists: About two cases.;BioMedicine;2024-02-28
2. One Rare Warfarin Resistance Case and Possible Mechanism Exploration;Pharmacogenomics and Personalized Medicine;2023-06
3. Missense VKOR mutants exhibit severe warfarin resistance but lack VKCFD via shifting to an aberrantly reduced state;Blood Advances;2022-12-12
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5. Recommendations for Clinical Warfarin Genotyping Allele Selection;The Journal of Molecular Diagnostics;2020-07
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