Non-selective beta-blockers may reduce risk of hepatocellular carcinoma: a meta-analysis of randomized trials

Author:

Thiele Maja1,Albillos Agustín2,Abazi Rozeta1,Wiest Reiner3,Gluud Lise L.4,Krag Aleksander1

Affiliation:

1. Department of Gastroenterology and Hepatology; Odense University Hospital; Odense Denmark

2. Department of Gastroenterology and Hepatology; Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBERehd); Institute of Health Carlos III; University Hospital Ramón y Cajal; University of Alcalá; IRYCIS; Madrid Spain

3. Department for Visceral Surgery and Medicine; University Hospital Bern; Bern Switzerland

4. Gastro unit; Copenhagen University Hospital Hvidovre; Hvidovre Denmark

Funder

University of Southern Denmark

Danish Advanced Technology Foundation

Publisher

Wiley

Subject

Hepatology

Reference51 articles.

1. IARC, WHO, Globocan Liver cancer estimated incidence, mortality and prevalence worldwide 2012 http://globocan.iarc.fr/Pages/fact_sheets_cancer.aspx

2. Epidemiology of viral hepatitis and hepatocellular carcinoma;El-Serag;Gastroenterology,2012

3. Reduced mortality with non-selective betablockers compared to banding is not related to prevention of bleeding or bleeding related mortality: systematic review of randomized trials;Krag;J Hepatol,2011

4. Can non-selective beta-blockers prevent hepatocellular carcinoma in patients with cirrhosis?;Thiele;Med Hypotheses,2013

5. The beta-adrenoceptor antagonist, propranolol, induces human gastric cancer cell apoptosis and cell cycle arrest via inhibiting nuclear factor kappaB signaling;Liao;Oncol Rep,2010

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