Low‐dose hydrocortisone in patients with COVID‐19 and severe hypoxia: The COVID STEROID randomised, placebo‐controlled trial

Author:

Munch Marie Warrer12ORCID,Meyhoff Tine Sylvest12ORCID,Helleberg Marie3,Kjær Maj‐Brit Nørregaard12ORCID,Granholm Anders12,Hjortsø Carl Johan Steensen12ORCID,Jensen Thomas Steen12,Møller Morten Hylander12ORCID,Hjortrup Peter Buhl12,Wetterslev Mik12ORCID,Vesterlund Gitte Kingo12ORCID,Russell Lene12,Jørgensen Vibeke Lind4,Kristiansen Klaus Tjelle5,Benfield Thomas6,Ulrik Charlotte Suppli7,Andreasen Anne Sofie8,Bestle Morten Heiberg2910,Poulsen Lone Musaeus11,Hildebrandt Thomas12,Knudsen Lene Surland13,Møller Anders14,Sølling Christoffer Grant15,Brøchner Anne Craveiro16,Rasmussen Bodil Steen217ORCID,Nielsen Henrik18,Christensen Steffen19,Strøm Thomas20,Cronhjort Maria21,Wahlin Rebecka Rubenson21,Jakob Stephan M.22,Cioccari Luca22,Venkatesh Balasubramanian2324,Hammond Naomi23,Jha Vivekanand242526,Myatra Sheila Nainan27,Jensen Marie Qvist1,Leistner Jens Wolfgang1,Mikkelsen Vibe Sommer1ORCID,Svenningsen Jens S.1,Laursen Signe Bjørn1,Hatley Emma Victoria1,Kristensen Camilla Meno1,Al‐Alak Ali6,Clapp Esben6,Jonassen Trine Bak6,Bjerregaard Caroline Løkke9,Østerby Niels Christian Haubjerg9,Jespersen Mette Mindedahl9,Abou‐Kassem Dalia8,Lassen Mathilde Languille8,Zaabalawi Reem14,Daoud Mohammed Mahmoud14,Abdi Suhayb14,Meier Nick1,Cour Kirstine11,Derby Cecilie Bauer11,Damlund Birka Ravnholt11,Laigaard Jens11,Andersen Lene Lund16,Mikkelsen Johan16,Jensen Jeppe Lundholm Stadarfeld16ORCID,Rasmussen Anders Hørby15,Arnerlöv Emil15,Lykke Mathilde15,Holst‐Hansen Mikkel Zacharias Bystrup19,Tøstesen Boris Wied19,Schwab Janne1928,Madsen Emilie Kabel19,Gluud Christian2930,Lange Theis31,Perner Anders12

Affiliation:

1. Department of Intensive Care RigshospitaletUniversity of Copenhagen Copenhagen Denmark

2. Collaboration for Research in Intensive Care (CRIC) Copenhagen Denmark

3. Department of Infectious Diseases RigshospitaletUniversity of Copenhagen Copenhagen Denmark

4. Department of Thoracic Anaesthesiology RigshospitaletUniversity of Copenhagen Copenhagen Denmark

5. Department of Anaesthesia and Intensive Care Copenhagen University Hospital—Amager and Hvidovre Hvidovre Denmark

6. Center of Research & Disruption of Infectious Diseases Department of Infectious Diseases Copenhagen University Hospital—Amager and Hvidovre Hvidovre Denmark

7. Department of Respiratory Medicine Copenhagen University Hospital—Amager and Hvidovre Hvidovre Denmark

8. Department of Anaesthesia and Intensive Care Herlev HospitalUniversity of Copenhagen Copenhagen Denmark

9. Department of Anaesthesia and Intensive Care Copenhagen University Hospital North Zealand Denmark

10. Department of Clinical Medicine University of Copenhagen Copenhagen Denmark

11. Department of Anaesthesiology Zealand University Hospital Køge Denmark

12. Department of Anaesthesia and Intensive Care Zealand University Hospital Roskilde Denmark

13. Department of Infectious Diseases Zealand University Hospital Roskilde Denmark

14. Department of Anaesthesia and Intensive Care Næstved‐Slagelse‐Ringsted Hospital Slagelse Denmark

15. Department of Anaesthesia and Intensive Care Viborg Hospital Viborg Denmark

16. Department of Anaesthesia and Intensive Care Kolding Hospital Kolding Denmark

17. Department of Anaesthesia and Intensive Care Aalborg University Hospital Aalborg Denmark

18. Department of Infectious Diseases Aalborg University Hospital Aalborg Denmark

19. Department of Anaesthesiology and Intensive Care Aarhus University Hospital Aarhus Denmark

20. Department of Anaesthesia and Intensive Care Odense University Hospital Odense Denmark

21. Department of Clinical Science and Education SödersjukhusetKarolinska Institutet Stockholm Sweden

22. Department of Intensive Care Medicine InselspitalBern University HospitalUniversity of Bern Bern Switzerland

23. The George Institute for Global HealthUniversity of New South Wales Sydney Australia

24. The George Institute for Global HealthUniversity of New South Wales New Delhi India

25. Prasanna School of Public Health Manipal Academy of Higher Education Manipal India

26. School of Public Health Imperial College London London UK

27. Department of Anaesthesia, Critical Care and Pain Tata Memorial HospitalHomi Bhabha National Institute Mumbai India

28. Flavour Institute Aarhus University Aarhus Denmark

29. Copenhagen Trial Unit Centre for Clinical Intervention Research The Capital Region of DenmarkRigshospitaletCopenhagen University Hospital Copenhagen Denmark

30. Department of Regional Health Research Faculty of Health Sciences The University of Southern Denmark Odense Denmark

31. Department of Public Health Section of Biostatistics University of Copenhagen Copenhagen Denmark

Funder

Pfizer

Publisher

Wiley

Subject

Anesthesiology and Pain Medicine,General Medicine

Reference29 articles.

1. The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2

2. World Health Organization.Novel Coronavirus (2019‐nCoV). Situation Report 22.https://www.who.int/docs/default‐source/coronaviruse/situation‐reports/20200211‐sitrep‐22‐ncov.pdf?sfvrsn=fb6d49b1_2. Accessed on March 18 2020.

3. COVID‐19 diagnosis and management: a comprehensive review

4. Low-dose corticosteroids for adult patients with septic shock: a systematic review with meta-analysis and trial sequential analysis

5. Effect of different doses and time‐courses of corticosteroid treatment in patients with acute respiratory distress syndrome: a meta‐analysis;Sun S;Exp Ther Med,2019

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