Ex vivo-expanded baboon CD39 + regulatory T cells prevent rejection of porcine islet xenografts in NOD-SCID IL-2rγ−/− mice reconstituted with baboon peripheral blood mononuclear cells
Author:
Affiliation:
1. Centre for Transplant and Renal Research; Westmead Millennium Institute; University of Sydney; Westmead NSW Australia
2. Cell Transplantation and Gene Therapy; 3 Xiangya Hospital of Central South University; Changsha China
Funder
National Health and Medical Research Council
Juvenile Diabetes Research Foundation
Publisher
Wiley
Subject
Transplantation,Immunology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/xen.12344/fullpdf
Reference33 articles.
1. Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates;Hering;Nat Med,2006
2. Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways;Cardona;Nat Med,2006
3. Islet xenotransplantation using gal-deficient neonatal donors improves engraftment and function;Thompson;Am J Transplant,2011
4. Long-term controlled normoglycemia in diabetic non-human primates after transplantation with hCD46 transgenic porcine islets;Windt;Am J Transplant,2009
5. Pig-to-monkey islet xenotransplantation using multi-transgenic pigs;Bottino;Am J Transplant,2014
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3. Cellular Immune Responses in Islet Xenograft Rejection;Frontiers in Immunology;2022-07-07
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