Depletion of high-affinity corticosteroid-binding globulin corresponds to illness severity in sepsis and septic shock; clinical implications

Author:

Nenke M.A.12,Rankin W.3,Chapman M.J.4,Stevens N.E.5,Diener K.R.56,Hayball J. D.25,Lewis J.G.7,Torpy D.J.1

Affiliation:

1. Endocrine and Metabolic Unit; Royal Adelaide Hospital; Adelaide SA Australia

2. School of Medicine; University of Adelaide; Adelaide SA Australia

3. Chemical Pathology Directorate; SA Pathology; Adelaide SA Australia

4. Intensive Care Unit; Royal Adelaide Hospital; Adelaide SA Australia

5. Experimental Therapeutics Laboratory; Hanson Institute and Sansom Institute; University of South Australia; Adelaide SA Australia

6. Robinson Research Institute and School of Paediatrics and Reproductive Health; University of Adelaide; Adelaide SA Australia

7. Steroid and Immunobiochemistry Laboratory; Canterbury Health Laboratories; Christchurch New Zealand

Funder

National Health and Medical Research Council

Australian Research Council

Royal Adelaide Hospital Research Fund

Publisher

Wiley

Subject

Endocrinology, Diabetes and Metabolism,Endocrinology

Reference26 articles.

1. Corticosteroid-binding globulin synthesis regulation by cytokines and glucocorticoids in human hepatoblastoma-derived (HepG2) cells;Emptoz-Bonneton;The Journal of Clinical Endocrinology and Metabolism,1997

2. Intact or “active” corticosteroid-binding globulin (CBG) and total CBG in plasma: determination by parallel ELISAs using monoclonal antibodies;Lewis;Clinica Chimica Acta,2013

3. Primary structure of human corticosteroid binding globulin, deduced from hepatic and pulmonary cDNAs, exhibits homology with serine protease inhibitors;Hammond;Proceedings of the National Academy of Sciences of the United States of America,1987

4. Hormone binding globulins undergo serpin conformational change in inflammation;Pemberton;Nature,1988

5. A role for corticosteroid-binding globulin in delivery of cortisol to activated neutrophils;Hammond;The Journal of Clinical Endocrinology and Metabolism,1990

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