Concentration‐QT modelling shows no evidence of clinically significant QT interval prolongation with capivasertib at expected therapeutic concentrations-Reference-Cited by-同舟云学术

Concentration‐QT modelling shows no evidence of clinically significant QT interval prolongation with capivasertib at expected therapeutic concentrations

Published:2021-09-28 Issue:2 Volume:88 Page:858-864
ISSN:0306-5251
Container-title:British Journal of Clinical Pharmacology
language:en
Short-container-title:Brit J Clinical Pharma

Author:

Voronova Veronika¹^ORCID,Cullberg Marie²^ORCID,Delff Philip³⁴,Parkinson Joanna²^ORCID,Dota Corina⁵,Schiavon Gaia⁶,Maroj Brijesh⁷,Rekić Dinko²,Cheung S. Y. Amy⁸⁹

Affiliation:

1. M&S Decisions LLC Moscow Russia

2. Clinical Pharmacology and Quantitative Pharmacology BioPharmaceuticals R&D, AstraZeneca R&D Gothenburg Sweden

3. Clinical Pharmacology and Quantitative Pharmacology BioPharmaceuticals R&D, AstraZeneca R&D Boston MA USA

4. Vertex Pharmaceuticals Boston MA USA

5. Cardiovascular Safety Center of Excellence Oncology R&D, AstraZeneca R&D Gothenburg Sweden

6. Late Development Oncology Oncology R&D, AstraZeneca R&D Cambridge UK

7. Patient Safety Oncology, Global Medicines Development AstraZeneca R&D Cambridge UK

8. Clinical Pharmacology and Quantitative Pharmacology BioPharmaceuticals R&D, AstraZeneca R&D Cambridge UK

9. Certara Princeton NJ USA

Funder

AstraZeneca Pharma Poland

Institute of Cancer Research

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/bcp.15006

Reference32 articles.

1. Signal Transduction Pathways in Breast Cancer: The Important Role of PI3K/Akt/mTOR

2. Targeting PI3K/Akt/mTOR Signaling in Cancer

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1. Pharmacokinetics of the Akt Serine/Threonine Protein Kinase Inhibitor, Capivasertib, Administered to Healthy Volunteers in the Presence and Absence of the CYP3A4 Inhibitor Itraconazole;Clinical Pharmacology in Drug Development;2023-07-14

2. Dostarlimab, an anti‐programmed death‐1 monoclonal antibody, does not cause QT prolongation in patients with solid tumours: A concentration‐QT analysis;British Journal of Clinical Pharmacology;2023-03-20

3. “The emerging role of capivasertib in breast cancer”;The Breast;2022-06