Heterozygote advantage at MHCDRBmay influence response to infectious disease epizootics

Author:

Osborne Amy J.12ORCID,Pearson John3,Negro Sandra S.4,Chilvers B. Louise5,Kennedy Martin A.2,Gemmell Neil J.1

Affiliation:

1. Department of Anatomy; University of Otago; PO Box 913 Dunedin 9054 New Zealand

2. Department of Pathology; University of Otago; Christchurch 8140 New Zealand

3. Department of Public Health and General Practice; University of Otago; Christchurch 8140 New Zealand

4. Génétique Quantitative et Méthologie de la Sélection; UMR de Génétique Végétale; INRA - Université Paris-Sud - CNRS - AgroParisTech; Ferme du Moulon; 91190 Gif-sur-Yvette France

5. Department of Conservation; Marine Species and Threats Team; Wellington 6011 New Zealand

Publisher

Wiley

Subject

Genetics,Ecology, Evolution, Behavior and Systematics

Reference82 articles.

1. High MHC diversity maintained by balancing selection in an otherwise genetically monomorphic mammal;Aguilar;Proceedings of the National Academy of Sciences of the United States of America,2004

2. The influence of parental relatedness on reproductive success;Amos;Proceedings of the Royal Society of London B - Biological Sciences,2001

3. What should we weigh to estimate heterozygosity, alleles or loci?;Aparicio;Molecular Ecology,2006

4. Resistance to three pathogens in the endangered winter-run chinook salmon (Oncorhynchus tshawytscha): effects of inbreeding and major histocompatibility complex genotypes;Arkush;Canadian Journal of Fisheries and Aquatic Sciences,2002

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