The circadian rhythm of corticosteroid‐binding globulin has little impact on cortisol exposure after hydrocortisone dosing

Author:

Melin Johanna12,Hartung Niklas13ORCID,Parra‐Guillen Zinnia P.14,Whitaker Martin J.5,Ross Richard J.6,Kloft Charlotte1

Affiliation:

1. Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy Freie Universitaet Berlin Berlin Germany

2. Graduate Research Training Program PharMetrX Berlin Germany

3. Institute of Mathematics University of Potsdam Potsdam Germany

4. Department of Pharmacy and Pharmaceutical Technology, Pharmacometrics and Systems Pharmacology, School of Pharmacy and Nutrition University of Navarra Pamplona Spain

5. Diurnal Limited Cardiff UK

6. University of Sheffield Sheffield UK

Funder

Seventh Framework Programme

Publisher

Wiley

Subject

Endocrinology, Diabetes and Metabolism,Endocrinology

Reference23 articles.

1. Diagnosis and treatment of primary adrenal insufficiency: an endocrine society clinical practice guideline;Bornstein SR;J Clin Endocrinol Metab,2016

2. Pharmacokinetics and oral bioavailability of hydrocortisone;Derendorf H;J Clin Pharm,1991

3. Oral hydrocortisone pharmacokinetics: a comparison of fluorescence and ultraviolet high‐pressure liquid;Toothaker RD;J Pharm Sci,1982

4. Bioavailability of oral hydrocortisone corrected for binding proteins and measured by LC‐MS/MS using serum cortisol and salivary cortisone;Johnson TN;J Bioequiv Bioavailab,2018

5. Weight‐related dosing, timing and monitoring hydrocortisone replacement therapy in patients with adrenal insufficiency;Mah PM;Clinical Endocrinol,2004

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