Nail abnormalities in subepidermal blistering diseases: a cross‐sectional study

Author:

Vafaeian Ahmad1ORCID,Ghanbarzadeh Arefeh1,Daneshpazhooh Maryam1ORCID,Abedini Robabeh1,Balighi Kamran1,Etesami Ifa1,Farid Ali Salehi1ORCID,Farimani Zeinab1,Mahmoudi Leila1,Azar Pedram Molhem1,Mahmoudi Hamidreza1ORCID

Affiliation:

1. Autoimmune Bullous Diseases Research Center Razi Hospital Tehran Iran

Abstract

AbstractBackgroundNail involvement in subepidermal autoimmune blistering diseases (SEABD) is not common. Although these changes can be transient, permanent changes can also occur. This study addresses nail involvement manifestations and their associated factors in patients with SEABD.MethodsFrom March 2020 to March 2021, we enrolled 56 patients with SEABD who were being examined at a tertiary skin hospital and checked their nail changes. We investigated the association between the SEABD subtypes and treatments that patients were receiving and the nail abnormalities. Additional factors including age, gender, duration since diagnosis, presence of mucosal involvement, and anti‐bp230 and anti‐bp180 IgG antibody quantitative levels (in those patients with bullous pemphigoid) were analyzed.ResultsThe most common nail abnormalities were ridging, onycholysis, and onychoschizia. We observed a lower prevalence of onycholysis in EBA, a lower prevalence of periungual bullae in MMP, and a higher prevalence of scarring loss in EBA. Rituximab and dapsone were effective in preventing onycholysis as well as prednisolone in preventing subungual hematoma. Multiple lesions were found to be more common in the foot digits including great toes, probably because of higher exposure to trauma.ConclusionsIn summary, in patients with SEABD and concomitant nail involvement, the underlying disease control, proper treatment, and avoidance of trauma may be helpful.

Publisher

Wiley

Subject

Dermatology

Reference45 articles.

1. Review of autoimmune blistering diseases: the Pemphigoid diseases

2. Neurological diseases and bullous pemphigoid: a case-control study in Iranian patients;Daneshpazhooh M;Indian J Dermatol Venereol Leprol,2017

3. Drug-induced pemphigoid: a review of the literature

4. Association of bullous pemphigoid with malignancy: A systematic review and meta-analysis

5. Bullous pemphigoid

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