Associations between higher plasma ferritin and hepcidin levels with liver stiffness in patients with type 2 diabetes: An exploratory study

Author:

Mantovani Alessandro1ORCID,Csermely Alessandro1ORCID,Castagna Annalisa2,Antinori Elisa2,Danese Elisa3,Zusi Chiara4,Sani Elena1,Ravaioli Federico5ORCID,Colecchia Antonio5,Maffeis Claudio4ORCID,Valenti Luca67ORCID,Girelli Domenico2,Targher Giovanni1ORCID

Affiliation:

1. Section of Endocrinology, Diabetes and Metabolism, Department of Medicine University of Verona and Azienda Ospedaliera Universitaria Integrata of Verona Verona Italy

2. Department of Medicine, Section of Internal Medicine, EuroBloodNet Center University of Verona and Azienda Ospedaliera Universitaria Integrata Verona Verona Italy

3. Section of Clinical Biochemistry, Department of Engineering for Innovation Medicine University of Verona Verona Italy

4. Pediatric Diabetes and Metabolic Disorders Unit, Department of Surgical Sciences, Dentistry, Pediatrics and Gynaecology University Hospital of Verona Verona Italy

5. Gastroenterology Unit, Department of Medical Specialities University Hospital of Modena, University of Modena & Reggio Emilia Modena Italy

6. Precision Medicine—Biological Resource Center, Transfusion Medicine Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico Milano Milan Italy

7. Department of Pathophysiology and Transplantation University of Milan Milan Italy

Abstract

AbstractBackgroundCurrently, there is no information about the association between circulating levels of ferritin and hepcidin and liver fibrosis in patients with type 2 diabetes mellitus (T2DM) and non‐alcoholic fatty liver disease (NAFLD).MethodsWe enrolled 153 patients with T2DM with no known liver diseases, who consecutively attended our diabetes outpatient service and who underwent liver ultrasonography and liver stiffness measurement (LSM) by vibration‐controlled transient elastography (Fibroscan® for the non‐invasive assessment of liver fibrosis). Plasma ferritin and hepcidin concentrations were measured with an electrochemiluminescence immunoassay and mass spectrometry‐based assay, respectively.ResultsAfter stratification of patients by LSM tertiles [1st tertile median LSM: 3.6 (interquartile range: 3.3–4.0) kPa, 2nd tertile: 5.3 (4.9–5.9) kPa and 3rd tertile: 7.9 (6.7–9.4) kPa], we found that plasma ferritin and hepcidin concentrations increased across LSM tertiles [median ferritin: 68.7 (interquartile range: 25.1–147) vs. 85.8 (48.3–139) vs. 111 (59.3–203) μg/L, p = 0.021; median hepcidin: 2.5 (1.1–5.2) vs. 4.4 (2.5–7.3) vs. 4.1 (1.9–6.8) nmol/L, p = 0.032]. After adjustment for age, sex, diabetes duration, waist circumference, haemoglobin A1c, HOMA‐insulin resistance score, triglycerides, haemoglobin, presence of hepatic steatosis on ultrasonography and patatin‐like phospholipase domain‐containing‐3 (PNPLA3) rs738409 genetic variant, higher plasma ferritin levels were associated with greater LSM values (adjusted‐odds ratio 2.10, 95% confidence interval 1.23–3.57, p = 0.005). Higher plasma hepcidin levels were also associated with greater LSM values (adjusted‐odds ratio 1.90, 95% confidence interval 1.15–3.13, p = 0.013).ConclusionsHigher levels of plasma ferritin and hepcidin were associated with greater NAFLD‐related liver fibrosis (assessed by LSM) in patients with T2DM, even after adjustment for established cardiometabolic risk factors, diabetes‐related variables and other potential confounders.

Publisher

Wiley

Subject

Hepatology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3