Antileukaemic effect of PI3K-mTOR inhibitors in acute myeloid leukaemia-gene expression profiles reveal CDC25B expression as determinate of pharmacological effect

Author:

Reikvam Håkon12,Tamburini Jerome3,Skrede Silje1,Holdhus Rita1,Poulain Laury3,Ersvaer Elisabeth1,Hatfield Kimberley J.12,Bruserud Øystein12

Affiliation:

1. Department of Clinical Science; University of Bergen; Bergen Norway

2. Division of Haematology; Department of Medicine; Haukeland University; Bergen Norway

3. Centre National de la Recherche Scientifique (CNRS, UMR8104); Paris and Service de Médecine Interne-UF d'Hématologie; Institut Cochin; Assistance Publique-Hopitaux de Paris; Université Paris Descartes; Paris France

Publisher

Wiley

Subject

Hematology

Reference42 articles.

1. CDC25 phosphatases in cancer cells: key players? Good targets?;Boutros;Nature Reviews Cancer,2007a

2. CDC25B involvement in the centrosome duplication cycle and in microtubule nucleation;Boutros;Cancer Research,2007b

3. Therapeutic targeting of NF-kappaB in myelodysplastic syndromes and acute myeloid leukaemia - the biological heterogeneity;Bruserud;Expert Opinion on Therapeutic Targets,2010

4. New strategies in the treatment of acute myelogenous leukemia (AML): in vitro culture of aml cells-the present use in experimental studies and the possible importance for future therapeutic approaches;Bruserud;Stem Cells,2001

5. Flt3-mediated signaling in human acute myelogenous leukemia (AML) blasts: a functional characterization of Flt3-ligand effects in AML cell populations with and without genetic Flt3 abnormalities;Bruserud;Haematologica,2003

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