Maternal early pregnancy body mass index and bipolar disorder in the offspring

Author:

Beer Rachael J.1,Cnattingius Sven2,Susser Ezra S.3,Wang Lu4,Villamor Eduardo1ORCID

Affiliation:

1. Department of Epidemiology University of Michigan School of Public Health Ann Arbor Michigan USA

2. Division of Clinical Epidemiology, Department of Medicine (Solna) Karolinska Institutet Stockholm Sweden

3. Department of Epidemiology, Mailman School of Public Health, Columbia University New York State Psychiatric Institute New York New York USA

4. Department of Biostatistics University of Michigan School of Public Health Ann Arbor Michigan USA

Abstract

AbstractObjectivesTo investigate the association between maternal early pregnancy body mass index (BMI) and offspring bipolar disorder (BPD).MethodsWe conducted a nationwide cohort study among 1,507,056 non‐malformed singleton live‐births in Sweden born 1983–2004. Using national registries with prospectively recorded information, we followed participants for a BPD diagnosis from ages 13 to up to 35 years. We compared BPD risks by early pregnancy BMI using hazard ratios (HR) with 95% confidence intervals (CI) from adjusted Cox models. We also conducted sibling‐controlled analyses among 874,047 full siblings.ResultsThere were 9970 BPD diagnoses. Risk of BPD was 0.72% through 25 years of age. Maternal early pregnancy BMI was positively associated with offspring BPD risk. Compared with normal BMI (18.5–24.9), adjusted HR (95% CI) for overweight (BMI 25–29.9), obesity grade 1 (BMI 30–34.9), and obesity grades 2–3 (BMI ≥35) were 1.08 (1.02, 1.15), 1.26 (1.14, 1.40), and 1.31 (1.07, 1.60), respectively. Adjusted HR per unit BMI was 1.015 (95% CI 1.009, 1.021). A similar trend was observed among siblings. Pregnancy and neonatal complications did not substantially mediate the association between maternal obesity (BMI ≥30) and offspring BPD.ConclusionsMaternal BMI ≥25 is associated with offspring BPD risk in a dose–response manner.

Funder

National Institute of Mental Health

Publisher

Wiley

Subject

Biological Psychiatry,Psychiatry and Mental health

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