First‐in‐human study of the safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple oral doses of SAR247799, a selective G‐protein‐biased sphingosine‐1 phosphate receptor‐1 agonist for endothelial protection

Author:

Bergougnan Luc1,Armani Sara2,Golor Georg2,Tardat Agnes3,Vitse Olivier3,Hurbin Fabrice3ORCID,Scemama Michel1,Poitiers Franck1,Radzik David1,Gaudin Christophe1,Hovsepian Lionel1,Muslin Anthony J.4,Kirkesseli Stephane1,Deutsch Paul5,Parkar Ashfaq A.5ORCID

Affiliation:

1. Sanofi R&D Chilly Mazarin France

2. Parexel International GmBH Berlin Germany

3. Sanofi R&D Montpellier France

4. Sanofi US Services Cambridge MA USA

5. Sanofi US Services Bridgewater NJ USA

Funder

Sanofi

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference33 articles.

1. The Vascular Endothelium and Human Diseases

2. Sphingosine-1-Phosphate Signaling in Endothelial Disorders

3. Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients;Schwab SR;Pharmacol Ther,2007

4. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

5. Gilenya (fingolimod) package insert. Basel Switzerland. Novartis pharmaceuticals2019.

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