Translational Model‐Informed Dose Selection for a Human Positron Emission Tomography Imaging Study of JNJ‐54175446, a P2X7 Receptor Antagonist-Reference-Cited by-同舟云学术

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Translational Model‐Informed Dose Selection for a Human Positron Emission Tomography Imaging Study of JNJ‐54175446, a P2X7 Receptor Antagonist

Published:2019-11-09 Issue:2 Volume:13 Page:309-317
ISSN:1752-8054
Container-title:Clinical and Translational Science
language:en
Short-container-title:Clin Transl Sci

Author:

Xu Yan¹,Miao Xin¹^ORCID,Ravenstijn Paulien²,Hijzen Anja³,Schmidt Mark E.³,Nandy Partha⁴,Zhou Honghui¹

Affiliation:

1. Clinical Pharmacology and Pharmacometrics Janssen Research & Development, LLC Springhouse Pennsylvania USA

2. Clinical Pharmacology and Pharmacometrics Janssen Research & Development, LLC Beerse Belgium

3. Neuroscience Experimental Medicine Janssen Research & Development, LLC Beerse Belgium

4. Clinical Pharmacology and Pharmacometrics Janssen Research & Development, LLC Titusville New Jersey USA

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/cts.12711

Reference20 articles.

1. 4-Methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate

2. Molecular Physiology of P2X Receptors

3. Tissue distribution of the P2X7 receptor

4. The P2X7Receptor: A Key Player in IL-1 Processing and Release

5. ATP-activated P2X7 receptor in the pathophysiology of mood disorders and as an emerging target for the development of novel antidepressant therapeutics

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Spotlight on P2X7 Receptor PET Imaging: A Bright Target or a Failing Star?;International Journal of Molecular Sciences;2023-01-10

2. P2X7 receptor in inflammation and pain;Brain Research Bulletin;2022-09

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