DNA‐Binding domain mutations confer severe outcome at an early age among STAT1 gain‐of‐function patients

Author:

Scott Ori1,Dadi Harjit12,Vong Linda12,Pasternak Yehonatan1,Garkaby Jenny1,Willett Pachul Jessica1,Mandola Amarilla B.3,Brager Rae4,Hostoffer Robert5,Nahum Amit36,Roifman Chaim M.12ORCID

Affiliation:

1. Division of Immunology and Allergy Department of Paediatrics Hospital for Sick Children and University of Toronto Toronto Ontario Canada

2. The Canadian Centre for Primary Immunodeficiency and The Jeffrey Modell Research Laboratory for the diagnosis of Primary Immunodeficiency The Hospital for Sick Children Toronto Ontario Canada

3. Pediatrics Department A Soroka University Medical Center Beer‐Sheva Israel

4. Division of Rheumatology, Immunology, and Allergy Department of Paediatrics McMaster Children's HospitalMcMaster University Hamilton Ontario Canada

5. Division of Pulmonary and Critical Care University Hospitals Cleveland Medical Center Cleveland Ohio USA

6. The Primary Immunodeficiency Research Laboratory Faculty of Health Sciences Ben‐Gurion University of the Negev Beer‐Sheva Israel

Funder

Canadian Child Health Clinician Scientist Program

Jeffrey Modell Foundation

Immunodeficiency Canada

Publisher

Wiley

Subject

Immunology,Immunology and Allergy,Pediatrics, Perinatology and Child Health

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