Complement C5 Inhibition Reduces T Cell-Mediated Allograft Vasculopathy Caused by Both Alloantibody and Ischemia Reperfusion Injury in Humanized Mice

Author:

Qin L.1,Li G.1,Kirkiles-Smith N.2,Clark P.2,Fang C.2,Wang Y.3,Yu Z.-X.3,Devore D.3,Tellides G.1,Pober J. S.2,Jane-Wit D.4

Affiliation:

1. Department of Surgery; Yale School of Medicine; New Haven CT

2. Department of Immunobiology; Yale School of Medicine; New Haven CT

3. Alexion Pharmaceuticals Inc.; New Haven CT

4. Department of Cardiovascular Medicine; Yale School of Medicine; New Haven CT

Funder

National Heart, Lung, and Blood Institute

Alexion Pharmaceuticals

Publisher

Wiley

Subject

Pharmacology (medical),Transplantation,Immunology and Allergy

Reference25 articles.

1. Long-term outcome after bare-metal or drug-eluting stenting for allograft coronary artery disease;Beygui;J Heart Lung Transplant,2010

2. Cardiac allograft vasculopathy;Lee;Rev Cardiovasc Med,2011

3. Mechanisms of chronic cardiac allograft rejection;Costello;Tex Heart Inst J,2013

4. Medication management of cardiac allograft vasculopathy after heart transplantation;Hollis;Pharmacotherapy,2015

5. Intimal arteritis in renal allografts: New takes on an old lesion;Bagnasco;Curr Opin Organ Transplant,2015

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