The use of dipyrone (metamizol) as an analgesic in children: What is the evidence? A review

Author:

de Leeuw Thomas G.1ORCID,Dirckx Maaike12,Gonzalez Candel Antonia1,Scoones Gail P.1,Huygen Frank J. P. M.2,de Wildt Saskia N.34

Affiliation:

1. Department of Anesthesiology; Erasmus MC-Sophia Children's Hospital; Rotterdam The Netherlands

2. Center for Pain Medicine; Erasmus MC; Rotterdam The Netherlands

3. Department of Pediatric Intensive Care and Pediatric Surgery; Erasmus MC-Sophia Children's Hospital; Rotterdam The Netherlands

4. Department of Pharmacology and Toxicology; Radboud University; Nijmegen The Netherlands

Publisher

Wiley

Subject

Anesthesiology and Pain Medicine,Pediatrics, Perinatology, and Child Health

Reference41 articles.

1. Pyrazolone derivatives;Brogden;Drugs,1986

2. Novel bioactive metabolites of dipyrone (metamizol);Rogosch;Bioorg Med Chem,2012

3. The analgesic effect of dipyrone in peripheral tissue involves two different mechanisms: neuronal K(ATP) channel opening and CB(1) receptor activation;Santos;Eur J Pharmacol,2014

4. Regulation of cyclooxygenase activity by metamizol;Campos;Eur J Pharmacol,1999

5. Single dose dipyrone for acute postoperative pain;Edwards;Cochrane Database Syst Rev,2010

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