Kevin Lafferty and the lymphocyte costimulator: theory and practice in Canberra

Author:

Hodgkin Philip D12ORCID

Affiliation:

1. Immunology Division The Walter and Eliza Hall Institute of Medical Research Parkville VIC Australia

2. Department of Medical Biology The University of Melbourne Melbourne VIC Australia

Abstract

AbstractBetween 1969 and 1983 the lab of Kevin Lafferty in Canberra developed the concept of the T‐cell “costimulator,” an essential second signal for activation. A great deal of the work appeared in this journal before it was known as Immunology & Cell Biology (ICB). As part of the 100‐year anniversary of the journal, I offer a personal reflection on Kevin's legacy and impact.

Funder

National Health and Medical Research Council

Publisher

Wiley

Subject

Cell Biology,Immunology,Immunology and Allergy

Reference44 articles.

1. Minimal model for the mechanism of antibody induction and paralysis by antigen;Bretscher PA;Nature,1968

2. A theory of self‐nonself discrimination;Bretscher P;Science,1970

3. Interleukin 2 production by alloantigen (H‐2) activated T cells;Andrus L;Aust J Exp Biol Med Sci,1981

4. A new analysis of allogeneic interactions;Lafferty KJ;Aust J Exp Biol Med Sci,1975

5. The origin and mechanism of the allograft reaction;Lafferty KJ;Immunol Rev,1977

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1. 100 years of Immunology & Cell Biology;Immunology & Cell Biology;2023-11

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