Circulating effector γδ T cell populations are associated with acute coronavirus disease 19 in unvaccinated individuals-Reference-Cited by-同舟云学术

Circulating effector γδ T cell populations are associated with acute coronavirus disease 19 in unvaccinated individuals

Published:2023-02-19 Issue:4 Volume:101 Page:321-332
ISSN:0818-9641
Container-title:Immunology & Cell Biology
language:en
Short-container-title:Immunol Cell Biol

Author:

von Borstel Anouk¹^ORCID,Nguyen Thi HO²,Rowntree Louise C²,Ashhurst Thomas M³⁴^ORCID,Allen Lilith F²,Howson Lauren J¹,Holmes Natasha E⁵⁶⁷⁸,Smibert Olivia C⁵⁹¹⁰,Trubiano Jason A⁸¹¹,Gordon Claire L²⁵,Cheng Allen C¹²¹³,Kent Stephen J²¹⁴¹⁵^ORCID,Rossjohn Jamie¹¹⁶¹⁷,Kedzierska Katherine²¹⁸^ORCID,Davey Martin S¹¹⁹^ORCID

Affiliation:

1. Infection and Immunity Program and Department of Biochemistry and Molecular Biology Biomedicine Discovery Institute, Monash University Clayton VIC Australia

2. Department of Microbiology and Immunology University of Melbourne, at the Peter Doherty Institute for Infection and Immunity Melbourne VIC Australia

3. Sydney Cytometry Core Research Facility, Charles Perkins Centre Centenary Institute and University of Sydney Sydney NSW Australia

4. Marie Bashir Institute for Infectious Diseases and Biosecurity University of Sydney Sydney NSW Australia

5. Department of Infectious Diseases Austin Health Heidelberg VIC Australia

6. Department of Critical Care University of Melbourne Parkville VIC Australia

7. Data Analytics Research and Evaluation (DARE) Centre Austin Health and University of Melbourne Heidelberg VIC Australia

8. Centre for Antibiotic Allergy and Research, Department of Infectious Diseases Austin Health Heidelberg VIC Australia

9. Department of Infectious Diseases Peter MacCallum Cancer Centre Melbourne VIC Australia

10. National Centre for Infections in Cancer Peter MacCallum Cancer Centre Melbourne VIC Australia

11. Department of Medicine (Austin Health) University of Melbourne Heidelberg VIC Australia

12. Infection Prevention and Healthcare Epidemiology Unit Alfred Health Melbourne VIC Australia

13. School of Public Health and Preventive Medicine Monash University Melbourne VIC Australia

14. ARC Centre of Excellence in Convergent Bio‐Nano Science and Technology University of Melbourne Melbourne VIC Australia

15. Melbourne Sexual Health Centre, Infectious Diseases Department, Alfred Health, Central Clinical School Monash University Melbourne VIC Australia

16. Australian Research Council Centre of Excellence in Advanced Molecular Imaging Monash University Clayton VIC Australia

17. Institute of Infection and Immunity Cardiff University School of Medicine, Heath Park Cardiff UK

18. Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education (GI‐CoRE) Hokkaido University Sapporo Japan

19. Division of Biomedical Sciences, Warwick Medical School University of Warwick Coventry UK

Abstract

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection causes severe coronavirus disease 2019 (COVID‐19) in a small proportion of infected individuals. The immune system plays an important role in the defense against SARS‐CoV‐2, but our understanding of the cellular immune parameters that contribute to severe COVID‐19 disease is incomplete. Here, we show that populations of effector γδ T cells are associated with COVID‐19 in unvaccinated patients with acute disease. We found that circulating CD27negCD45RA+CX3CR1+ Vδ1effector cells expressing Granzymes (Gzms) were enriched in COVID‐19 patients with acute disease. Moreover, higher frequencies of GzmB+ Vδ2+ T cells were observed in acute COVID‐19 patients. SARS‐CoV‐2 infection did not alter the γδ T cell receptor repertoire of either Vδ1+ or Vδ2+ subsets. Our work demonstrates an association between effector populations of γδ T cells and acute COVID‐19 in unvaccinated individuals.

Funder

Australian Research Council

Department of Education and Early Childhood Development, State Government of Victoria

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Jack Brockhoff Foundation

National Health and Medical Research Council

Rebecca L. Cooper Medical Research Foundation

Royal Society

Publisher

Wiley

Subject

Cell Biology,Immunology,Immunology and Allergy