Characterization ofP. falciparumdipeptidyl aminopeptidase 3 specificity identifies differences in amino acid preferences between peptide‐based substrates and covalent inhibitors

Author:

Vries Laura E.1ORCID,Sanchez Mateo I.2,Groborz Katarzyna3,Kuppens Laurie4,Poreba Marcin3,Lehmann Christine4,Nevins Neysa5,Withers‐Martinez Chrislaine6,Hirst David J.7,Yuan Fang8,Arastu‐Kapur Shirin8,Horn Martin9,Mares Michael9,Bogyo Matthew8,Drag Marcin3,Deu Edgar4

Affiliation:

1. Department of Medical Microbiology Radboud University Medical Center Nijmegen The Netherlands

2. Department of Genetics Stanford School of Medicine Stanford CA USA

3. Division of Bioorganic Chemistry Faculty of Chemistry Wroclaw University of Technology Wroclaw Poland

4. Chemical Biology Approaches to Malaria Laboratory The Francis Crick Institute London UK

5. Computational Sciences GlaxoSmithKline Collegeville PA USA

6. Malaria Biochemistry The Francis Crick Institute London UK

7. Crick‐GSK Biomedical LinkLabs GlaxoSmithKline Stevenage UK

8. Department of Pathology Stanford University School of Medicine Stanford CA USA

9. Institute of Organic Chemistry and Biochemistry Czech Academy of Sciences Prague Czech Republic

Funder

European Regional Development Fund

Royal Society

Wellcome Trust

Publisher

Wiley

Subject

Cell Biology,Molecular Biology,Biochemistry

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