Affiliation:
1. Laboratory of Periodontal Biology, Faculty of Dentistry Universidad de Chile Santiago Chile
2. Department of Conservative Dentistry, Faculty of Dentistry Universidad de Chile Santiago Chile
3. Laboratory of Oral Biology, Faculty of Dentistry Universidad Finis Terrae Santiago Chile
4. Department of Pathology and Oral Medicine, Faculty of Dentistry Universidad de Chile Santiago Chile
5. Faculty of Dentistry Universidad Andres Bello Santiago Chile
Abstract
AbstractAimTo determine the systemic inflammatory burden, including hsCRP and its monomeric forms, in patients with apical lesions of endodontic origin treated with root canal treatment (RCT).MethodologyProspective pre‐/post‐study. Apical periodontitis (AP) individuals aged 16–40 were included (N = 29). Individuals received RCT and were followed at 1 and 6 months. Fasting blood samples were obtained. Apical lesions of endodontic origin (ALEO) diameter (mm), and periapical index (PAI), were recorded. The serum concentrations of total hsCRP were determined by turbidimetry. Tumour necrosis factor (TNF)‐α, interleukin (IL)‐6, IL‐10, IL‐1β, and soluble (s) E‐selectin were assessed by Multiplex assay. Additionally, mCRP forms were determined in the serum of AP patients with a baseline moderate to high cardiovascular risk based on hsCRP stratification (hsCRP ≥1 mg/L) by immunowestern blot (n = 15). Also, CRP isoforms were explored in ALEOs from AP individuals (n = 4). Data were analysed with StataV16.ResultsPeriapical index and ALEO sizes were reduced at both follow‐up visits after RCT (p < .05). Serum levels of TNF‐α, IL‐6, IL‐10, IL‐1β, and sE‐selectin did not show significant differences. CRP was borderline reduced at 1 month (p = .04); however, in AP individuals at cardiovascular risk (hsCRP ≥ 1 mg/L), hsCRP and its monomeric isoform significantly decreased at 1 and 6 months (p < .05).ConclusionsHigh‐sensitivity CRP and mCRP are reduced after RCT in AP individuals at cardiovascular risk.
Funder
Fondo Nacional de Desarrollo Científico y Tecnológico
Agencia Nacional de Investigación y Desarrollo
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