T-cell signaling pathways inhibited by the tick saliva immunosuppressor, Salp15

Author:

Juncadella Ignacio J.,Garg Renu,Ananthnarayanan Shobana K.,Yengo Christopher M.,Anguita Juan

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical),General Medicine,Immunology,Microbiology,Immunology and Allergy

Reference20 articles.

1. Alonso A , Bottini N , Bruckner S , Rahmouni S , Williams S , Schoenberger SP & Mustelin T (2004) Lck dephosphorylation at Tyr-394 and inhibition of T cell antigen receptor signaling by Yersinia phosphatase YopH. J Biol Chem 279: 4922–4928.

2. Anguita J , Ramamoorthi N , Hovius JW et al. (2002) Salp15, an Ixodes scapularis salivary protein, inhibits CD4+ T cell activation. Immunity 16: 849–859.

3. Bolen JB & Brugge JS (1997) Leukocyte protein tyrosine kinases: potential targets for drug discovery. Annu Rev Immunol 15: 371–404.

4. Bustelo XR (2000) Regulatory and signaling properties of the Vav family. Mol Cell Biol 20: 1461–1477.

5. Crespo P , Schuebel KE , Ostrom AA , Gutkind JS & Bustelo XR (1997) Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product. Nature 385: 169–172.

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