STAT4 expression and activation is increased during mitosisin vitroandin vivoin skin- and mucosa-derived cell types: implications in neoplastic and inflammatory skin diseases

Author:

Ferreli C.12,Lai C.13,August S.13,Buggy Y.1,Kumar P.1,Brownlow N.4,Parker P.4,Friedmann P.S.13,Ardern-Jones M.13,Pickard C.1,Healy E.13

Affiliation:

1. Dermatopharmacology, Clinical and Experimental Sciences; Sir Henry Wellcome Laboratories; Faculty of Medicine; University of Southampton; Southampton Hampshire UK

2. Dermatology Unit; Department of Medical Sciences; Public Health University of Cagliari; Cagliari Italy

3. Dermatology; University Hospital Southampton NHS Foundation Trust; Southampton Hampshire UK

4. London Research Institute; Lincoln's Inn Fields; London UK

Funder

National Institute for Health Research

Publisher

Wiley

Subject

Infectious Diseases,Dermatology

Reference51 articles.

1. JAK and STAT signaling molecules in immunoregulation and immune-mediated disease;O'Shea;Immunity,2012

2. STATs in cancer inflammation and immunity: a leading role for STAT3;Yu;Nat Rev Cancer,2009

3. Signal transducers and activators of transcription-from cytokine signalling to cancer biology;Santos;Biochim Biophys Acta,2011

4. Roles of unphosphorylated STATs in signaling;Yang;Cell Res,2008

5. Activation of STAT4 by IL-12 and IFN-alpha: evidence for the involvement of ligand-induced tyrosine and serine phosphorylation;Cho;J Immunol,1996

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