Therapeutic factor VIII does not trigger TLR1.2 and TLR2.6 signallingin vitro
Author:
Publisher
Wiley
Subject
Genetics(clinical),Hematology,General Medicine
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/hae.12081/fullpdf
Reference26 articles.
1. Incidence of development of factor VIII and factor IX inhibitors in haemophiliacs;Ehrenforth;Lancet,1992
2. Why do inhibitors develop? Principles of and factors influencing the risk for inhibitor development in haemophilia;Astermark;Haemophilia,2006
3. A role for thrombin in the initiation of the immune response to therapeutic factor VIII;Skupsky;Blood,2009
4. Shannon L Meeks M Courtney Cox MS et al Factor VIII Structure, Not Activity, Is the Primary Determinant of Immunogenicity in Hemophilia A and Combined Hemophilia A/Von Willebrand Disease Mice San diego, CA, USA 2011
5. Toll-like receptors and their crosstalk with other innate receptors in infection and immunity;Kawai;Immunity,2011
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1. Implementing a Clinical Immunogenicity Strategy using Preclinical Risk Assessment Outputs;Journal of Pharmaceutical Sciences;2022-04
2. Hemophilia A Inhibitor Subjects Show Unique PBMC Gene Expression Profiles That Include Up-Regulated Innate Immune Modulators;Frontiers in Immunology;2020-06-12
3. Origine et nature de la réponse immunitaire neutralisante contre le facteur VIII thérapeutique;médecine/sciences;2020-04
4. Pathogenic immune response to therapeutic factor VIII: exacerbated response or failed induction of tolerance?;Haematologica;2018-12-04
5. Inhibitor Formation in Congenital Hemophilia A: an Immunological Perspective;Seminars in Thrombosis and Hemostasis;2018-06-04
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