The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells
Author:
Affiliation:
1. Department of Biochemical Sciences Sapienza University of Rome Italy
2. Istituto di Biologia e Patologia Molecolari Consiglio Nazionale delle Ricerche Rome Italy
Funder
Sapienza Università di Roma
Associazione Italiana per la Ricerca sul Cancro
Publisher
Wiley
Subject
Cell Biology,Molecular Biology,Biochemistry
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1111/febs.14610
Reference30 articles.
1. Serine and Functional Metabolites in Cancer
2. Serine and glycine metabolism in cancer
3. Exploiting Metabolic Vulnerabilities of Cancer with Precision and Accuracy
4. A pyrazolopyran derivative preferentially inhibits the activity of human cytosolic serine hydroxymethyltransferase and induces cell death in lung cancer cells
5. Screening and In Vitro Testing of Antifolate Inhibitors of Human Cytosolic Serine Hydroxymethyltransferase
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