Inhibition of Cdc42 activity extends lifespan and decreases circulating inflammatory cytokines in aged female C57BL/6 mice-Reference-Cited by-同舟云学术

Inhibition of Cdc42 activity extends lifespan and decreases circulating inflammatory cytokines in aged female C57BL/6 mice

Published:2020-08-04 Issue:9 Volume:19 Page:
ISSN:1474-9718
Container-title:Aging Cell
language:en
Short-container-title:Aging Cell

Author:

Florian Maria Carolina¹²^ORCID,Leins Hanna²,Gobs Michael³,Han Yang³,Marka Gina²,Soller Karin²,Vollmer Angelika²,Sakk Vadim²,Nattamai Kalpana J.⁴,Rayes Ahmad⁴,Zhao Xueheng⁵,Setchell Kenneth⁵,Mulaw Medhanie⁶,Wagner Wolfgang³^ORCID,Zheng Yi⁴,Geiger Hartmut²

Affiliation:

1. Program of Regenerative Medicine IDIBELL Barcelona Spain

2. Institute of Molecular Medicine and Stem Cell Aging Ulm University Ulm Germany

3. Helmholtz‐Institute for Biomedical Engineering Stem Cell Biology and Cellular Engineering RWTH Aachen University Medical School Aachen Germany

4. Division of Experimental Hematology and Cancer Biology Cincinnati Children's Hospital Medical Center University of Cincinnati Cincinnati Ohio USA

5. Division of Pathology Cincinnati Children's Hospital Medical Center University of Cincinnati Cincinnati Ohio USA

6. Institute of Experimental Cancer Research Medical Faculty University of Ulm Ulm Germany

Funder

Deutsche Forschungsgemeinschaft

Publisher

Wiley

Subject

Cell Biology,Ageing

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/acel.13208

Reference36 articles.

1. DNA methylation aging clocks: challenges and recommendations

2. Remodeling of epigenome and transcriptome landscapes with aging in mice reveals widespread induction of inflammatory responses

3. Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice

4. The lifespan quantitative trait locus gene Securin controls hematopoietic progenitor cell function

5. From discoveries in ageing research to therapeutics for healthy ageing

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