Recent advances in CAR‐T cell therapy for acute myeloid leukaemia

Author:

Gao Chi1ORCID,Li Xin2,Xu Yao1ORCID,Zhang Tongcun13,Zhu Haichuan1,Yao Di1ORCID

Affiliation:

1. College of Life Science and Health Wuhan University of Science and Technology Wuhan China

2. College of Biotechnology Tianjin University of Science and Technology Tianjin China

3. Institute of Biology and Medicine Wuhan University of Science and Technology Wuhan China

Abstract

AbstractAcute myeloid leukaemia (AML) is a fatal and refractory haematologic cancer that primarily affects adults. It interferes with bone marrow cell proliferation. Patients have a 5 years survival rate of less than 30% despite the availability of several treatments, including chemotherapy, allogeneic haematopoietic stem cell transplantation (Allo‐HSCT), and receptor antagonist drugs. Allo‐HSCT is the mainstay of acute myeloid leukaemia treatment. Although it does work, there are severe side effects, such as graft‐versus‐host disease (GVHD). In recent years, chimeric antigen receptor (CAR)‐T cell therapies have made significant progress in the treatment of cancer. These engineered T cells can locate and recognize tumour cells in vivo and release a large number of effectors through immune action to effectively kill tumour cells. CAR‐T cells are among the most effective cancer treatments because of this property. CAR‐T cells have demonstrated positive therapeutic results in the treatment of acute myeloid leukaemia, according to numerous clinical investigations. This review highlights recent progress in new targets for AML immunotherapy, and the limitations, and difficulties of CAR‐T therapy for AML.

Funder

Wuhan Science and Technology Project

Publisher

Wiley

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